PMID: 20630132Jul 16, 2010Paper

Association of immune cell function assay with protocol biopsy findings and viral infections in well matched kidney transplant recipients

Clinical Nephrology
I Helanterä, P Koskinen

Abstract

Cylex Immune Cell Function Assay (ICFA) is in clinical use, but little is known about its association with screening of viral infections or findings in protocol biopsies. We analyzed ICFA in our well-matched kidney transplant population. Helsinki University Hospital patients who received a kidney transplant after July 2007 were analyzed. Patients with at least 6 months follow-up and ICFA measured together with the screening for cytomegalovirus (CMV), or polyomaviruses from urine or plasma, or patients with a protocol biopsy at 6 or 12 months taken at the time of the ICFA were included (n = 27). Immunosuppression was usually implemented with mycophenolate mofetil (MMF), steroids and cyclosporine A (CyA). Biopsies were analyzed with chronic allograft damage index (CADI). Mean immune response in 61 samples was 368 +/- 179 ATP ng/ml. Immune response was lower during BK virus (BKV) or CMV viremia compared to no viremia (p = 0.009 and p = 0.017), and no viremia was seen if immune response was > 380. BK or JC viruria was not associated with low immune response. Immune responses did not differ between patients with high or low CADI scores or between patients with immune activation or no immune activation in biopsies. Immune response in...Continue Reading

Citations

Apr 18, 2012·Nature Reviews. Nephrology·Dirk R J Kuypers
Jul 20, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Jean El-CheikhDidier Blaise
Jul 22, 2014·Pediatric Transplantation·Vikas R Dharnidharka, Laura E Hesemann
Nov 25, 2014·Pediatric Transplantation·Akinari FukudaMureo Kasahara
Jul 1, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·María Asunción Pérez-Jacoiste AsínJosé Maria Aguado
Apr 21, 2011·Expert Review of Anti-infective Therapy·Javier CarboneElizabeth Sarmiento

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