Association of impaired baroreflex sensitivity and increased arterial stiffness in peritoneal dialysis patients

Clinical and Experimental Nephrology
Amit GuptaSanjay Kumar Agarwal

Abstract

Peritoneal dialysis patients have high cardiovascular morbidity and mortality. The underlying mechanism of cardiovascular dysfunction remains unclear. Large arterial stiffness in chronic kidney disease (CKD) patients leads to increase in pulse wave velocity (PWV) and decrease in baroreflex sensitivity (BRS). Impairment in baroreflex function could be attributed to the alteration in mechanical properties of large vessels due to arterial remodeling observed in these patients. The present study was designed to study the association of BRS and PWV in peritoneal dialysis (PD) patients. 42 CKD patients (21--without dialysis and 21--on PD) and 25 healthy controls were recruited in this study. BRS was determined by spontaneous sequence method. Short-term heart rate variability (HRV) and blood pressure variability (BPV) were assessed using power spectrum analysis of RR intervals and systolic blood pressure by time domain and frequency domain analysis. Arterial stiffness indices were assessed by carotid-femoral PWV using Sphygmocor Vx device (AtCor Medical, Australia). CKD patients had significantly high PWV and low BRS as compared to healthy controls. PWV had a significant negative correlation with BRS in CKD patients (Spearman r = -0.7...Continue Reading

References

Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K D MonahanH Tanaka
Aug 13, 2002·Journal of Hypertension·Daniela LuciniMassimo Pagani
Feb 9, 2005·Kidney International·Sunita BavanandanThompson G Robinson
Apr 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lindsay J ChestertonChristopher W McIntyre
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adrian CovicDavid J A Goldsmith
May 5, 2006·Kidney International·P StudingerM Kollai
Nov 16, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Reena RanpuriaMark Unruh
May 3, 2008·Kidney International. Supplement·S G JohnC W McIntyre
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dvora RubingerDan Sapoznikov
Dec 19, 2009·American Journal of Hypertension·Raymond R TownsendMarshall Joffe
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ada W Y ChungAdeera Levin
Jan 13, 2012·American Journal of Nephrology·Cheuk-Chun SzetoPhilip Kam-Tao Li
Feb 2, 2012·Frontiers in Physiology·Cara M Hildreth
Jul 12, 2012·International Journal of Clinical Practice·R HajhosseinyD J Goldsmith
Jun 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manpreet KaurSanjay Kumar Agarwal
Apr 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirofumi TomiyamaAkira Yamashina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.