Association of impaired endothelial glycocalyx with arterial stiffness, coronary microcirculatory dysfunction, and abnormal myocardial deformation in untreated hypertensives.

The Journal of Clinical Hypertension
Ignatios IkonomidisJohn Lekakis

Abstract

We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment of coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives and 160 controls. We measured perfused boundary region (PBR) of the sublingual microvessels, a marker inversely related with glycocalyx thickness, coronary flow reserve (CFR), and Global Longitudinal strain (GLS) by echocardiography, pulse wave velocity (PWV), and central systolic blood pressure (cSBP). Hypertensives had higher PBR, PWV cSBP, and lower CFR and GLS than controls (P < .05). In hypertensives, increased PBR was associated with increased cSBP, PWV, and decreased CFR and GLS after adjustment for age, sex, BMI, smoking LV mass, heart rate, hyperlipidemia, and office SBP (P < .05). PBR had an additive value to PWV, CFR, and office SBP for the prediction of abnormal GLS (x2  = 2.4-3.8, P for change = .03). Endothelial glycocalyx is impaired in untreated hypertensives and is related to arterial stiffness, coronary, and myocardial dysfunction.

References

Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·A W Mulivor, H H Lipowsky
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shimon A ReisnerZvi Friedman
Jun 21, 2005·Journal of the American College of Cardiology·Yuichi NotomiJames D Thomas
Apr 6, 2006·Journal of Internal Medicine·M GouverneurH Vink
Jan 27, 2007·Pflügers Archiv : European journal of physiology·Sietze ReitsmaMirjam G A oude Egbrink
Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Apr 10, 2007·Trends in Cardiovascular Medicine·Jurgen W Van TeeffelenHans Vink
Mar 6, 2008·QJM : Monthly Journal of the Association of Physicians·M I M NobleH Vink
Aug 12, 2009·Microvascular Research·S Speziale, S Sivaloganathan
May 14, 2010·Cardiovascular Research·Bernhard F BeckerMatthias Jacob
Sep 23, 2010·Basic Research in Cardiology·Bernhard F BeckerMatthias Jacob
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·John LekakisCharalambos Vlachopoulos
Jul 29, 2011·Pflügers Archiv : European journal of physiology·Hans OberleithnerKilian Oberleithner
Nov 8, 2011·Drug Discovery Today. Disease Models·Herbert H Lipowsky
Jul 28, 2012·Biorheology·Xuewen Yin, Junfeng Zhang
Oct 23, 2012·Journal of the American Society of Nephrology : JASN·Carmen A VlahuHans Vink
Feb 13, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Bingmei M Fu, John M Tarbell
Dec 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans Oberleithner
Jul 18, 2014·Journal of cardiovascular ultrasound·Yoshihiro SeoKazutaka Aonuma
Feb 11, 2015·Blood Purification·Hans Oberleithner, Marianne Wilhelmi
Mar 18, 2015·British Journal of Clinical Pharmacology·Bernhard F BeckerDaniel Chappell
Jun 8, 2015·Current Opinion in Cardiology·Ignatios IkonomidisJohn Lekakis
Jan 11, 2016·Journal of Internal Medicine·J M Tarbell, L M Cancel
Sep 13, 2016·Journal of Intensive Care·Akira UshiyamaTakehiko Iijima

❮ Previous
Next ❯

Citations

Oct 14, 2018·The Journal of Clinical Hypertension·Helen TriantafyllidiIgnatios Ikonomidis
Nov 14, 2018·European Journal of Clinical Investigation·Ignatios IkonomidisEfstathios Iliodromitis
Apr 13, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Boris SchmitzStefan-Martin Brand
May 27, 2020·Basic Research in Cardiology·Ilona CuijpersEbba Brakenhielm
Nov 7, 2019·Clinical Hemorheology and Microcirculation·David AstapenkoVladimir Cerny
Nov 2, 2018·Journal of Clinical Medicine·Jesus F Bermejo-MartinRaquel Almansa
Sep 23, 2020·Cardiovascular Engineering and Technology·Sheldon WeinbaumJohn M Tarbell
Mar 28, 2019·PloS One·Luca ValerioSara-Joan Pinto-Sietsma
Jan 1, 2020·Current Vascular Pharmacology·Emmanouil KorakasVaia Lambadiari
Aug 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ignatios IkonomidisEfstathios Iliodromitis
Feb 18, 2021·Acta Anaesthesiologica Scandinavica·Robert G HahnRandal O Dull
May 26, 2021·Nano Letters·Piyumi WijesekaraXi Ren
Jul 31, 2021·PloS One·Elisabeth Buur StougaardPeter Rossing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.