Association of incidental emphysema with annual lung function decline and future development of airflow limitation

International Journal of Chronic Obstructive Pulmonary Disease
Hyeon-Kyoung KooChang-Hoon Lee

Abstract

Emphysema is one of the prognostic factors for rapid lung function decline in patients with COPD, but the impact of incidentally detected emphysema on population without spirometric abnormalities has not been evaluated. This study aimed to determine whether emphysema detected upon computed tomography (CT) screening would accelerate the rate of lung function decline and influence the possibility of future development of airflow limitation in a population without spirometric abnormalities. Subjects who participated in a routine screening for health checkup and follow-up pulmonary function tests for at least 3 years between 2004 and 2010 were retrospectively enrolled. The percentage of low-attenuation area below -950 Hounsfield units (%LAA-950) was calculated automatically. A calculated value of %LAA-950 that exceeded 10% was defined as emphysema. Adjusted annual lung function decline was analyzed using random-slope, random-intercept mixed linear regression models. A total of 628 healthy subjects within the normal range of spriometric values were included. Multivariable analysis showed that the emphysema group exhibited a faster decline in forced vital capacity (-33.9 versus -18.8 mL/year; P=0.02). Emphysema was not associated wit...Continue Reading

Citations

Feb 7, 2018·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezJadwiga A Wedzicha
Apr 25, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Joshua GawlitzaThomas Henzler
Mar 31, 2017·The European Respiratory Journal·James A StockleyElizabeth Sapey
Nov 20, 2020·American Journal of Respiratory and Critical Care Medicine·MeiLan K HanClaus F Vogelmeier
Oct 30, 2020·Journal of Clinical Medicine·Joon Young Choi, Chin Kook Rhee

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