Association of increased B7 protein expression by infiltrating immune cells with progression of gastric carcinogenesis

Medicine
Lingchuan GuoXue-Guang Zhang

Abstract

B7 negative costimulatory molecules are a group of molecules associated with the occurrence, development, and therapy of cancers. Here, we aimed to determine the clinical significance of PD-L1, B7-H3, and B7-H4 and their expression in CD8 and CD68 positive cells at different stages of gastric carcinogenesis.We detected PD-L1, B7-H3, B7-H4, CD8, and CD68 expression in samples by immunohistochemical staining of 62 chronic superficial gastritis (CSG) samples, 72 chronic atrophic gastritis (CAG) samples, 68 low-grade intraepithelial neoplasia (LIN) samples, 65 high-grade intraepithelial neoplasia (HIN) samples obtained from gastroscopic biopsies and 50 gastric adenocarcinoma (GA) samples obtained from surgical resections. Then we statistically analyzed the expression differences and correlations.Our results indicated that B7 and CD68 expression on infiltrating immune cells was associated with disease progression. However, infiltration of CD8+ cells decreased with disease progression. B7-H3 expression was markedly enhanced at neoplasia and GA stages. B7-H3 in tumor cells was negatively correlated with CD8-expressing cells. Conversely, B7-H3 expression in tumor-infiltrating immune cells was positively correlated with CD68-expressing ...Continue Reading

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Citations

Oct 3, 2019·Cancers·Theodoulakis ChristofiApostolos Zaravinos
Mar 15, 2020·Journal of Leukocyte Biology·Maria Grazia RefoloRosalba D'Alessandro
May 18, 2019·Current Medicinal Chemistry·Karine Flem-KarlsenCaroline E Nunes-Xavier
Dec 11, 2020·Expert Opinion on Biological Therapy·Theodoros MichelakosSoldano Ferrone
Mar 7, 2021·International Journal of Molecular Sciences·Dita UlaseChristoph Röcken
Aug 31, 2021·World Journal of Gastrointestinal Oncology·Petar RasicDjordje Savic
Oct 9, 2021·Frontiers in Cell and Developmental Biology·Shenglei SongChanghua Zhang

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Methods Mentioned

BETA
biopsies
biopsy
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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