Association of Increased Chronicity of Depression With HIV Appointment Attendance, Treatment Failure, and Mortality Among HIV-Infected Adults in the United States

JAMA Psychiatry
Brian W PenceMichael J Mugavero

Abstract

Depression commonly affects adults with HIV and complicates the management of HIV. Depression among individuals with HIV tends to be chronic and cyclical, but the association of this chronicity with HIV outcomes (and the related potential for screening and intervention to shorten depressive episodes) has received little attention. To examine the association between increased chronicity of depression and multiple HIV care continuum indicators (HIV appointment attendance, treatment failure, and mortality). The study comprised an observational clinical cohort of 5927 patients with 2 or more assessments of depressive severity who were receiving HIV primary care at 6 geographically dispersed US academic medical centers from September 22, 2005, to August 6, 2015. Missing a scheduled HIV primary care visit, detectable HIV RNA viral load (≥75 copies/mL), and all-cause mortality. Consecutive depressive severity measures were converted into a time-updated measure: percentage of days with depression (PDD), following established methods for determining depression-free days. During 10 767 person-years of follow-up, the 5927 participants (5000 men, 926 women, and 1 intersex individual; median age, 44 years [range, 35-50 years]) had a median ...Continue Reading

References

Jul 22, 1998·Archives of General Psychiatry·J R LaveM S Kamlet
Mar 23, 2001·JAMA : the Journal of the American Medical Association·J R IckovicsUNKNOWN HIV Epidemiology Research Study Group
May 1, 2001·The American Journal of Psychiatry·J A Ciesla, J E Roberts
Oct 3, 2002·The American Journal of Psychiatry·Dwight L EvansJohn M Petitto
Jul 1, 2004·American Journal of Public Health·Judith A CookNancy A Hessol
Apr 28, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brian Wells PenceBradley N Gaynes
Dec 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brian Wells PenceJoseph J Eron
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nancy A HessolMardge H Cohen
May 15, 2007·Medical Care·Jeffrey M PyneJohn Fortney
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C KaplanStephen J Gange
Oct 9, 2007·AIDS Patient Care and STDs·Michael J MugaveroNathan M Thielman
Nov 3, 2007·The American Journal of Psychiatry·Jane LesermanDalene Stangl
Feb 12, 2008·International Journal of Epidemiology·Mari M KitahataMichael S Saag
Nov 28, 2008·Statistical Methods in Medical Research·Miguel A HernánDominique Costagliola
Jun 3, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Audrey L FrenchMardge H Cohen
Dec 17, 2009·American Journal of Epidemiology·Stephen R ColeMichael S Saag
Feb 4, 2010·Psychiatric Services : a Journal of the American Psychiatric Association·Steven D VannoyJürgen Unützer
Nov 24, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brian Wells PenceKathryn Whetten
May 15, 2012·Current Psychiatry Reports·Brian W PenceBradley N Gaynes
Jun 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J MugaveroMelanie A Thompson
Nov 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith A Aberg Infectious Diseases Society of America
Apr 22, 2015·General Hospital Psychiatry·Bradley N GaynesBrian W Pence
Aug 19, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mardge H CohenKathleen M Weber
Nov 7, 2015·AIDS Patient Care and STDs·Julie Ann ZunigaDrenna Waldrop-Valverde
Apr 22, 2017·American Journal of Epidemiology·Jonathan V ToddAdaora A Adimora

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Citations

Jan 25, 2019·Expert Opinion on Pharmacotherapy·Amedeo Capetti, Giuliano Rizzardini
Apr 6, 2019·AIDS·Robert H RemienClaude A Mellins
Oct 29, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey A Kelly
Jul 30, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew E LevyAmanda D Castel
Jul 25, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jon C MillsAdaora A Adimora
Mar 21, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Emily W PaolilloDavid J Moore
Oct 9, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Jackson CurrieAllison R Webel
Jul 16, 2020·Evidence-based Mental Health·Cesar GarrigaMaría Angeles Rodríguez-Arenas
Jul 26, 2018·JAMA : the Journal of the American Medical Association·Michael S SaagPaul A Volberding
Aug 14, 2019·Current Opinion in HIV and AIDS·Bridget A Bunda, Ingrid V Bassett
Jul 1, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael J LiSteven J Shoptaw
Jan 12, 2019·Journal of Behavioral Medicine·Neil SchneidermanMichael H Antoni
Jan 16, 2021·AIDS and Behavior·Cecile M DenisDwight L Evans
Aug 28, 2020·AIDS Research and Human Retroviruses·Stephanie ShiauDavid J Moore
Feb 19, 2021·AIDS and Behavior·Mathilda ReganChristopher R Sudfeld
Mar 7, 2021·Brain Sciences·Marina NosikOxana Svitich
Mar 11, 2021·AIDS Patient Care and STDs·Amanda Blair SpenceSeble Kassaye
May 19, 2021·Journal of Neurovirology·Adam R DentonRosemarie M Booze
Jun 6, 2021·Human Brain Mapping·Margarita BronshteynXiong Jiang
Nov 19, 2021·Psychology, Health & Medicine·Thu Minh BuiRoger C M Ho
Nov 19, 2021·Current HIV/AIDS Reports·Jacqueline HoareNicole Phillips
Dec 11, 2021·Research in Nursing & Health·Christine Horvat DaveyAllison Webel

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