Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
V CatalánG Frühbeck

Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation. The association of circulating NAMPT concentrations with obesity has not been clearly established. The aim of the present work was to evaluate the effect of obesity on circulating concentrations and gene expression levels of NAMPT in human peripheral blood cells (PBCs) as well as its involvement in inflammation, glucose and lipid metabolism. Forty-four serum samples obtained from 14 lean and 30 obese volunteers were used to analyse the circulating concentrations of NAMPT. In addition, PBC, omental adipose tissue (OM) and liver biopsy samples obtained from a subgroup of subjects were used to determine transcript levels of NAMPT by Real-time PCR. Glucose and lipid profile as well as several inflammatory factors and hepatic enzymes were analysed. NAMPT circulating concentrations (P<0.01) and gene expression levels in PBC (P<0.05) were significantly increased in obese patients as compared to lean subjects. Total-cholesterol (P=0.016), HDL-cholesterol (P=0.036) and triglycerides (P=0.050) were significant and independent determinants of circulating concentrat...Continue Reading

Citations

Sep 18, 2010·Molecules and Cells·Jae Geun KimByung Ju Lee
Sep 18, 2010·Mediators of Inflammation·Zhaoxia Wang, Tomohiro Nakayama
Dec 24, 2011·TheScientificWorldJournal·Morena ScoteceOreste Gualillo
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May 16, 2014·Frontiers in Endocrinology·Ana I Pérez-HernándezGema Frühbeck
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Aug 10, 2019·Journal of Clinical Medicine·Eloi Franco-TrepatRodolfo Gómez
May 16, 2020·Frontiers in Cell and Developmental Biology·Weiqi HongXiawei Wei

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