Association of indoor nitrogen dioxide with respiratory symptoms in children: application of measurement error correction techniques to utilize data from multiple surrogates

Journal of Exposure Science & Environmental Epidemiology
Ruifeng LiD Spiegelman

Abstract

In 1991, Neas et al. reported that indoor nitrogen dioxide (NO(2)), a byproduct of high-temperature combustion, was significantly associated with lower respiratory symptoms among a cohort of 1,159 white children aged 7-11 years in six US cities studied from 1983 to 1988. For each 15 p.p.b. increment of NO(2), the multivariate adjusted odds ratio (OR) was 1.4 (95% confidence interval (CI)=[1.1, 1.7]). Although indoor NO(2) concentration in the ambient air was assessed only in a subset of the children, the prevalence of lower respiratory symptoms and surrogate exposure variables were available in all of the children at the time of the indoor monitoring program. This paper evaluates the effect of indoor NO(2) exposure on the annual risk of lower respiratory symptoms by applying a regression calibration method to the 2,891 children in the overall study with complete covariate and outcome data, 1,137 of whom had NO(2) directly measured and 1,754 of whom only surrogate exposure data were available. An estimate of the indoor annual NO(2) exposure effect (p.p.b.) is obtained, which is adjusted for measurement error induced by the use of surrogate NO(2) sources among the 1,754. These sources include the presence of a gas stove with or w...Continue Reading

Citations

Jan 15, 2010·Annual Review of Public Health·Donna Spiegelman
Feb 24, 2018·International Archives of Occupational and Environmental Health·Matthias Möhner
Jul 20, 2018·Journal of the Air & Waste Management Association·Frederick W Lipfert, Ronald E Wyzga
Nov 26, 2016·Environmental Health : a Global Access Science Source·Kathie L DionisioLisa K Baxter

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