Association of Induced Hyperhomocysteinemia with Alzheimer's Disease-Like Neurodegeneration in Rat Cortical Neurons After Global Ischemia-Reperfusion Injury

Neurochemical Research
M KovalskaJ Lehotsky

Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that results in massive hippocampal and neocortical neuronal loss leading to dementia and eventual death. The exact cause of Alzheimer's disease is not fully explored, although a number of risk factors have been recognized, including high plasma concentration of homocysteine (Hcy). Hyperhomocysteinemia (hHcy) is considered a strong, independent risk factor for stroke and dementia. However, the molecular background underlying these mechanisms linked with hHcy and ischemic stroke is not fully understood. Paper describes rat model of global forebrain ischemia combined with the experimentally induced hHcy. Global ischemia-reperfusion injury (IRI) was developed by 4-vessels occlusion lasting for 15 min followed by reperfusion period of 72 h. hHcy was induced by subcutaneous injection of 0.45 µmol/g of Hcy in duration of 14 days. The results showed remarkable neural cell death induced by hHcy in the brain cortex and neurodegeneration is further aggravated by global IRI. We demonstrated degeneration of cortical neurons, alterations in number and morphology of tissue astrocytes and dysregulation of oxidative balance with increased membrane protein oxi...Continue Reading

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Citations

Dec 17, 2019·Aging·Xin Chen, Hua Jiang
Oct 5, 2018·Journal of Alzheimer's Disease : JAD·Ryszard PlutaStanisław J Czuczwar
Feb 6, 2020·International Journal of Molecular Sciences·Marzena Ułamek-KoziołRyszard Pluta
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Oct 17, 2018·International Journal of Molecular Sciences·Barbara TóthováJán Lehotský
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Dec 15, 2019·International Journal of Molecular Sciences·Maria KovalskaJan Lehotsky
Dec 14, 2018·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jul 2, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jan 23, 2021·International Journal of Molecular Sciences·Hendrik NieraadGerd Geisslinger
Apr 1, 2021·Neurotoxicity Research·Angela T S WyseAndré Quincozes-Santos
Jul 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ahmed M ShehataLamberto Re

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Methods Mentioned

BETA
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Adobe Photoshop CS3
GraphPad Prism
Quick Photo Micro
Gene Tools
Olympus Fluoview FV10 - ASW
ImageJ

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