Association of Infant Antibiotic Exposure With Childhood Health Outcomes.

Mayo Clinic Proceedings
Zaira AversaNathan K LeBrasseur

Abstract

To investigate the extent to which antibiotic exposure in the first 2 years of life is associated with the risk of immunological, metabolic, and neurobehavioral health conditions with childhood onset. In this population-based cohort study, we identified all children born in Olmsted County, Minnesota, between January 1, 2003, and December 31, 2011, through the Rochester Epidemiology Project medical records-linkage system. Demographic characteristics, antibiotic prescriptions, and diagnostic codes through June 30, 2017, were retrieved using the Rochester Epidemiology Project infrastructure. Time-to-event analysis was performed to assess the impact of antibiotic exposure on the risk of several adverse health conditions. This study included 14,572 children (7026 girls and 7546 boys), of whom 70% (10,220) received at least 1 antibiotic prescription during the first 2 years of life. Early antibiotic exposure was associated with an increased risk of childhood-onset asthma, allergic rhinitis, atopic dermatitis, celiac disease, overweight, obesity, and attention deficit hyperactivity disorder (hazard ratios ranging from 1.20 to 2.89; P<.05 for all). The associations were influenced by the number, type, and timing of antibiotic exposure....Continue Reading

References

Apr 7, 2007·Chest·Anita L KozyrskyjAllan B Becker
Nov 20, 2012·International Journal of Epidemiology·Jennifer L St SauverWalter A Rocca
Jan 26, 2013·Epidemiology·Johanna MetsäläSuvi M Virtanen
Dec 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lauren Hoskin-ParrA J W Henderson
Jul 12, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B AzadA L Kozyrskyj
Sep 30, 2014·JAMA Pediatrics·L Charles BaileyPatricia A DeRusso
Mar 17, 2015·Journal of Psychiatric Research·Timothy G DinanJohn F Cryan
Apr 16, 2015·The New England Journal of Medicine·Daniel A Leffler, J Thomas Lamont
Oct 2, 2015·Science Translational Medicine·Marie-Claire ArrietaB Brett Finlay
Apr 30, 2016·Science·Thomas GensollenRichard S Blumberg
May 4, 2016·JAMA : the Journal of the American Medical Association·Katherine E Fleming-DutraLauri A Hicks
Jun 17, 2016·Science Translational Medicine·Nicholas A BokulichMartin J Blaser
Aug 27, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A G HirschB S Schwartz
Sep 23, 2016·JAMA : the Journal of the American Medical Association·Hilary D MarstonAnthony S Fauci
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Oct 27, 2016·Nature Microbiology·Alexandra E LivanosMartin J Blaser
Nov 7, 2016·The Lancet. Diabetes & Endocrinology·De-Kun LiRoxana Odouli
Mar 17, 2017·Annual Review of Neuroscience·Helen E VuongElaine Y Hsiao
Mar 28, 2017·Nestlé Nutrition Institute Workshop Series·Meghan B AzadShadi Sepehri
Jul 28, 2017·Nature Reviews. Immunology·Martin J Blaser
Sep 2, 2017·PloS One·Esther AartsAlejandro Arias Vasquez
Oct 21, 2017·JAMA Pediatrics·Kaisa M KemppainenUNKNOWN Environmental Determinants of Diabetes in the Young (TEDDY) Study Group
Jan 13, 2018·Nature Communications·Jakob StokholmHans Bisgaard
Aug 14, 2018·International Journal of Epidemiology·Amani F HamadI Fan Kuo
Aug 24, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Paul Bryde AxelssonEllen Christine Leth Løkkegaard
Oct 3, 2018·Epidemiology·Paul Bryde AxelssonEllen Christine Leth Løkkegaard
Oct 27, 2018·Science·Andrew H MoellerMichael W Nachman

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Citations

Jan 14, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alain CunaVenkatesh Sampath
Jul 11, 2021·Advances in Pediatrics·Kurlen S E Payton, Marissa A Brunetti
Jul 31, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Xin MengZuxun Lu
Aug 27, 2021·The New England Journal of Medicine·Prasanth PattisapuSpencer E Lindsey
Aug 27, 2021·The New England Journal of Medicine·Jack L ParadiseDiego Preciado
Aug 18, 2021·International Journal of Clinical Practice·Samah F Al-ShatnawiRawand A Khasawneh

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