Association of inflammatory factors and aging in Parkinson's disease.

Neuroscience Letters
Hong JinChun-Feng Liu

Abstract

Parkinson's disease as a common neurodegenerative disease, has been found to be related to inflammation. So we observed the characteristics of inflammatory indexes in patients with Parkinson's disease and investigated the relationship between inflammatory cytokines and clinical characteristics. Emerging data may reveal novel neuroinflammatory pathways and identify new targets for treatment of Parkinson's disease. We examined the inflammatory indexes in 183 patients and 89 healthy controls in association with clinical characteristics. Patients had significantly higher levels of monocytes, neutrophils, high-sensitivity C-reactive protein, and monocyte-to-high-density lipoprotein ratios (p < 0.01) and lower levels of lymphocytes (p = 0.02) than the controls. There were no significant differences in age, leukocytes, high-density lipoprotein, or neutrophil-lymphocyte ratios between the two groups (p > 0.05). Multivariate logistic regression analysis of these indicators revealed that lymphocyte level was a protective factor (p = 0.025, OR=-0.679), while high-sensitivity C-reactive protein level was a risk factor (p = 0.000, OR=1.168) for Parkinson's disease. High-sensitivity C-reactive protein levels were higher in older Parkinson's ...Continue Reading

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Citations

Jun 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Laura Muñoz-DelgadoPablo Mir
Aug 1, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sonat Pınar KaraAysun Unal

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