Association of insertion/deletion polymorphism of the angiotensin-converting enzyme gene with angio-oedema accompanying chronic urticaria but not chronic urticaria without angio-oedema or the autologous serum skin test response

Journal of the European Academy of Dermatology and Venereology : JEADV
C AkcaliA S Aynacioglu

Abstract

Chronic urticaria is defined as the daily or almost daily occurrence of weals for more than 6 weeks. The underlying pathophysiology is reported to be mast cell activation, with release of mast cell mediators, predominantly histamine. Substance P is a neuropeptide and has the capacity to provoke histamine release from skin mast cells. Angiotensin-converting enzyme (ACE), widely expressed in skin, is one of the major peptidase for the degradation of substance P. An insertion/deletion polymorphism (I/D) in the ACE gene has been reported to be related to the levels of enzyme. An increase in substance P levels due to a polymorphism in ACE gene might be related to the pathology. Thus, we aimed to investigate whether there is an association between ACE I/D polymorphism and chronic ordinary urticaria. Ninety-five patients with chronic ordinary urticaria were recruited and divided into two groups according to autologous serum skin test status and accompanying angio-oedema. One hundred and sixty-one healthy subjects were enrolled as control group. All participants were genotyped for I/D polymorphism in intron 16 of the ACE gene by polymerase chain reaction. A statistically significant association was not found between ACE I/D polymorphis...Continue Reading

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Citations

Feb 18, 2010·Indian Journal of Dermatology·Sanjay Ghosh
Apr 25, 2018·Frontiers in Immunology·Marcus MaurerMartin Metz
Oct 16, 2019·Frontiers in Genetics·Itahisa Marcelino-RodriguezCarlos Flores
Aug 28, 2020·Frontiers in Genetics·Itahisa Marcelino-RodriguezCarlos Flores

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