Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus

American Journal of Obstetrics and Gynecology
Ekrem C TokSaffet Dilek

Abstract

Insulin receptor substrate-1 (IRS-1) expression and tyrosine phosphorylation is decreased during pregnancy. Pregnancy may be a suitable condition to detect any abnormalities related to IRS-1 polymorphisms. Therefore, we aimed to investigate the prevalence and metabolic impacts of IRS-1 G972R polymorphism in patients with gestational diabetes mellitus (GDM). Anthropometric and metabolic variables of 62 women who were diagnosed as having GDM according to 100 g oral glucose tolerance test were compared on the basis of IRS-1 polymorphism by univariate analysis of covariance. Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels. Weight gain during pregnancy and insulin and glucose levels after glucose ingestion was comparable between groups. IRS-1 G972R was associated with the baseline characteristics of the patients with GDM, and might be related to insulin resistance that is seen in obese patients with GDM.

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Citations

Jan 12, 2013·Current Diabetes Reports·Marilyn LacroixMarie-France Hivert
May 22, 2013·Human Reproduction Update·Cuilin ZhangMichele Kiely
Apr 17, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Julie Robitaille, Althea M Grant
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Mar 14, 2007·Current Opinion in Obstetrics & Gynecology
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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