PMID: 6166810Jan 1, 1981Paper

Association of insulinoma with subcutaneous nodular fat necrosis

Journal of Surgical Oncology
R A Schwartz, J S Fleishman

Abstract

A 57-year-old man first noted tender subcutaneous nodules on his extremities and abdomen. Six months later symptoms of insulin hypersecretion became evident and hyperinsulinemia was documented. An exploratory laparotomy revealed an islet cell tumor measuring 12 cm in diameter extending anteriorly from head of the pancreas with metastases in the liver. Evidence of parathyroid and pituitary hormone hypersecretion suggests that the insulinoma may be part of a multiple endocrine neoplasia syndrome. Histological examination of the subcutaneous nodules revealed the characteristic histology of nodular fat necrosis. This is the first report of the association of an insulin-secreting islet cell carcinoma with subcutaneous nodular fat necrosis.

References

Jan 1, 1979·The American Journal of Dermatopathology·J L MillnsR K Winkelmann
Jan 1, 1968·Annals of Internal Medicine·G T MullinR C Williams
Jun 1, 1968·The British Journal of Dermatology·A Macdonald, M Feiwel
May 1, 1967·The British Journal of Dermatology·P de Graciansky
Feb 1, 1980·The Journal of Dermatology·H IshizakiA Himi

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Citations

Jun 1, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K HasenöhrlM Meurer
Dec 1, 1981·Current Problems in Cancer·F Montenegro-Rodas, N A Samaan
Dec 17, 2008·Clinical and Experimental Dermatology·L SagiH Trau
Aug 16, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R de W MarshF P Flowers
Oct 10, 2014·Endocrinology, Diabetes & Metabolism Case Reports·P HansonT M Barber

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