Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults

JAMA Oncology
Wanshui YangXuehong Zhang

Abstract

Increased intake of whole grain and dietary fiber has been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for hepatocellular carcinoma (HCC). Therefore, we hypothesized that long-term intake of whole grains and dietary fiber may be associated with lower risk of HCC. To assess the associations of whole grain and dietary fiber intake with the risk of HCC. Cohort study of the intake of whole grains, their subcomponents (bran and germ), and dietary fiber (cereal, fruit, and vegetable) in 125 455 participants from 2 cohorts from the Nurses' Health Study and the Health Professionals Follow-up Study. Intake of whole grains, their subcomponents (bran and germ), and dietary fiber (cereal, fruit, and vegetable) were collected and updated almost every 4 years using validated food frequency questionnaires. Multivariable hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards regression model after adjusting for most known HCC risk factors. After an average follow-up of 24.2 years, we identified 141 patients with HCC among 125 455 participants (77 241 women and 48 214 men (mean [SD] age, 63.4 [10.7] years). Increased whole grain intake was sign...Continue Reading

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Citations

Nov 7, 2019·The American Journal of Gastroenterology·Xiao LuoXuehong Zhang
Aug 12, 2020·The American Journal of Clinical Nutrition·Evan Y W YuMaurice P Zeegers
Nov 20, 2019·Cancers·Ram C ShankaraiahMassimo Negrini
Apr 3, 2020·The British Journal of Nutrition·Wan-Shui YangYong-Bing Xiang
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Sep 15, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Yu ZhuWanshui Yang
Sep 19, 2021·Cancer Medicine·Iman MoussaManal M Hassan

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