Association of Intensive Lifestyle Intervention, Fitness, and Body Mass Index With Risk of Heart Failure in Overweight or Obese Adults With Type 2 Diabetes Mellitus: An Analysis From the Look AHEAD Trial.

Circulation
Ambarish PandeyLook AHEAD Research Group

Abstract

Type 2 diabetes mellitus (T2DM) is associated with a higher risk for heart failure (HF). The impact of a lifestyle intervention and changes in cardiorespiratory fitness (CRF) and body mass index on risk for HF is not well established. Participants from the Look AHEAD trial (Action for Health in Diabetes) without prevalent HF were included. Time-to-event analyses were used to compare the risk of incident HF between the intensive lifestyle intervention and diabetes support and education groups. The associations of baseline measures of CRF estimated from a maximal treadmill test, body mass index, and longitudinal changes in these parameters with risk of HF were evaluated with multivariable adjusted Cox models. Among the 5109 trial participants, there was no significant difference in the risk of incident HF (n=257) between the intensive lifestyle intervention and the diabetes support and education groups (hazard ratio, 0.96 [95% CI, 0.75-1.23]) over a median follow-up of 12.4 years. In the most adjusted Cox models, the risk of HF was 39% and 62% lower among moderate fit (tertile 2: hazard ratio, 0.61 [95% CI, 0.44-0.83]) and high fit (tertile 3: hazard ratio, 0.38 [95% CI, 0.24-0.59]) groups, respectively (referent group: low fit, ...Continue Reading

Associated Clinical Trials

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Citations

Feb 10, 2021·JAMA : the Journal of the American Medical Association·Ambarish Pandey, Dalane W Kitzman
Nov 22, 2020·International Journal of Molecular Sciences·Felipe ArroyaveFernando Lizcano
Oct 2, 2020·Progress in Cardiovascular Diseases·Andrew ElagiziHector O Ventura
Apr 26, 2021·Diabetes Research and Clinical Practice·Paul ValensiErwan Donal
Jun 11, 2021·Journal of the American Heart Association·Arnaud D KazeJustin B Echouffo-Tcheugui
Jun 24, 2021·Cardiovascular Diabetology·Lorenzo NestiAndrea Natali
Jun 15, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nitin KondamudiAmbarish Pandey

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BETA
GM104940

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