Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Tsung-Po ChenChao-Bin Yeh

Abstract

Intercellular adhesion molecule-1 (ICAM-1) is a human protein encoded by the ICAM-1 gene and is typically expressed on endothelial cells and immune cells. ICAM-1 is associated with episode, growth, invasion, and metastasis of hepatocellular carcinoma (HCC). However, the association between ICAM-1 genetic variants and the risk of HCC is undetermined. In this study, we investigated the potential associations of ICAM-1 single nucleotide polymorphisms (SNPs) with susceptibility to HCC and its clinicopathological characteristics. A total of 918 participants, including 613 controls participants and 305 patients with HCC, were selected for the analysis of ICAM-1 SNPs (rs3093030, rs5491, rs281432, and rs5498) by using real-time PCR genotyping. After adjusting for covariants of age, sex, and alcohol consumption, 125 smoker patients with HCC carrying at least one G genotype (AG and GG) in rs5498 were observed to have a higher HCC risk compared with 231 smoker control participants carrying the wild-type allele AA (adjusted odds ratio (AOR), 1.713; 95 % confidence interval (CI), 1.091-2.690; P = 0.019). However, patients who possess at least one polymorphic allele of rs5498 are less prone to develop vascular invasive (AOR, 0.309; 95 % CI, ...Continue Reading

References

Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MomosakiM Kojiro
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShimizuA Watanabe
Aug 1, 1993·Journal of Surgical Oncology·A ToriiH Takagi
Jun 8, 2001·The Journal of Biological Chemistry·C D JunT A Springer
Jan 5, 2002·Cancer Immunology, Immunotherapy : CII·W J KöstlerC C Zielinski
Jan 31, 2002·World Journal of Gastroenterology : WJG·Ming-Hui MeiLi-Ling Qin
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Mario MelisMark Gjomarkaj
May 31, 2006·Human Genetics·Hankui ChenRick A Kittles
Feb 20, 2007·Current Medicinal Chemistry·Hanako KobayashiP Charles Lin
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jan 3, 2012·Thrombosis Research·Violetta Dymicka-PiekarskaHalina Kemona
Feb 2, 2012·World Journal of Gastroenterology : WJG·Meng-Meng TianJi-You Li
Feb 1, 2013·International Journal of Cancer. Journal International Du Cancer·Yu UsamiSatoru Toyosawa
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xi-Wen Zhu, Jian-Ping Gong
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Umit YilmazIlhan Yaylim
Jan 31, 2014·Journal of Clinical Laboratory Analysis·Ming-Chang HsiehMing-Hsien Chien
May 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shian-Shiang WangShun-Fa Yang
May 12, 2016·Stroke; a Journal of Cerebral Circulation·Mariana SelwanessMeike W Vernooij

❮ Previous
Next ❯

Citations

May 6, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Amel G ElsheredyTamer Haydara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.