Association of interferon-alpha-induced depression and improved treatment response in patients with hepatitis C

Neuroscience Letters
Jennifer M LoftisPeter Hauser

Abstract

Thirty-nine patients with hepatitis C viral infection on interferon-alpha (IFN-alpha) therapy were monitored weekly using the Beck Depression Inventory (BDI). Thirteen of thirty-nine patients (33%) developed IFN-alpha-induced major depressive disorder (MDD). During the course of IFN-alpha therapy, patients who became depressed were treated with citalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant. Results indicated that: (1) IFN-alpha response rates were significantly higher in those patients who developed IFN-alpha-induced MDD than in those who did not (end-of-treatment response (ETR) rates: 61.5% versus 26.9% and sustained viral response (SVR) rates: 38.5% versus 11.5%), (2) male patients with ETR to IFN-alpha therapy were, on average, approximately 33 pounds lighter in body weight than male patients who did not respond, and (3) gender, race, past history of MDD, and past history of substance abuse were not significantly associated with ETR. In conclusion, our findings suggest that IFN-alpha-induced MDD may be a predictor of a positive response to IFN-alpha therapy, or an indication of optimal dosing.

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Citations

May 25, 2007·Current Psychiatry Reports·Brian Keefe
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Francis E LotrichPeter Hauser
Apr 25, 2006·Journal of Clinical Gastroenterology·Gregory M Asnis, Richard De La Garza
Apr 12, 2007·Journal of Clinical Gastroenterology·Adrian W DollarhideJonathan M Meyer
Oct 19, 2004·Journal of Affective Disorders·Jennifer M Loftis, Peter Hauser
Jan 30, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·D E Fransen Van De PutteE P Mauser-Bunschoten
Mar 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Salvatore Maria CorselloFrancesco Torino
Sep 16, 2009·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sanjeev Sockalingam, Susan E Abbey
Jun 22, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·D E Fransen van de PutteE P Mauser-Bunschoten
Jan 5, 2018·International Journal of Psychiatry in Medicine·Jeffrey J WeissJack M Gorman
Aug 30, 2008·The American Journal of Gastroenterology·Robert J FontanaUNKNOWN HALT-C Trial Group
Oct 18, 2011·General Hospital Psychiatry·Bruno Cópio FábregasAntônio Lúcio Teixeira

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