Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population.

Human Genetics
K W CarterLyle J Palmer

Abstract

The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in the Interleukin-1 (IL-1) gene family are associated with central obesity and metabolic syndrome in a coronary heart disease population. The IL-1 alpha C-889T (rs1800587) and IL-1 beta +3954 (rs1143634) SNPs were studied in a Western Australian coronary heart disease (CHD) population (N = 556). Subjects who were TT homozygous at either SNP had larger waist circumference (IL-1 alpha: 1.8 cm greater, P = 0.04; IL-1 beta: 4 cm greater, P = 0.0004) compared with major allele homozygotes. Individuals with two copies of the IL-1 alpha:IL-1 beta T:T haplotype had greater waist circumference (4.7 cm greater, P = 0.0001) compared to other haplotypes. There was a significant interaction between the IL-1 beta SNP and BMI level on waist circumference (P = 0.01). When the cohort was stratified by median BMI, TT carriers for IL-1 beta with above median BMI had greater waist circumference (6.1 cm greater, P = 0.007) compared to baseline carriers, whilst no significant association was seen in the below median group. Similarly, when the cohort was stratified by median fibrinogen level (IL-1 alpha interaction P = 0.01; IL-1 beta interaction P = 0.04), T...Continue Reading

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Citations

Feb 9, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yulan ZhaoChew-Kiat Heng
Sep 11, 2012·European Journal of Clinical Pharmacology·Diana Lacruz-GuzmánPablo Conesa-Zamora
Dec 27, 2008·BMC Bioinformatics·Kim W CarterLyle J Palmer
Apr 2, 2009·Journal of Periodontology·Peng LiQing-Xian Luan
Oct 17, 2012·Molecular Aspects of Medicine·Carey N Lumeng
Mar 10, 2011·International Journal of Immunogenetics·T FurutaT Nakashima
Oct 13, 2016·Alimentary Pharmacology & Therapeutics·J E NelsonUNKNOWN NASH Clinical Research Network
Oct 27, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Ayse Feyda NursalSerbulent Yigit
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Jan 4, 2013·The American Journal of Clinical Nutrition·Miriam F RyanMichael J Gibney
Aug 12, 2009·Molecular and Cellular Endocrinology·M F Manica-CattaniI B M Cruz

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