Association of interleukin-1beta gene and receptor antagonist polymorphisms with calcium oxalate urolithiasis

Journal of Endourology
Rama D MittalRakesh Kapoor

Abstract

Genetic polymorphisms of the interleukin-1beta (IL-1beta) promoter region (-511) and exon 5 +3954 and a variable number of tandem repeats in the IL receptor antagonist (IL-1RA) gene have been proposed as markers for calcium oxalate urolithiasis. Because the prevalence of these polymorphisms could be influenced by racial variation/ethnicity, we explored the association of IL-1 gene-cluster polymorphisms with stone formation in a north India population. The case-control study involved 150 stone-free control subjects (mean age 46.5 +/- 10.5 years) and 130 patients (mean age 40.0 +/- 11.5 years) with calcium oxalate urolithiasis. Biallelic polymorphisms of two loci, IL-1beta (-511) and IL-1beta (+3954), as well as the penta-allelic variable number of tandem repeats of IL-1RA, were genotyped by polymerase chain reaction-based restriction analysis. Haplotypes were constructed for the IL-1 gene cluster using SNP Analyzer software. We observed a significant association between stone disease and IL-1beta -511 and IL-1RA polymorphisms (P < 0.001 and P = 0.039, respectively), whereas no association was observed for IL-1beta +3954 (P = 0.408). The frequency of the TT (-511) and I/II (410/240; IL-1RA) genotypes was higher in patients than i...Continue Reading

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Citations

Apr 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Rama D MittalRakesh Kapoor
Jun 3, 2014·BMC Medical Genetics·Nanyawan RungrojPa-Thai Yenchitsomanus
Nov 20, 2013·TheScientificWorldJournal·Paul A DawsonDavid Cowley
Jul 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sung Hye YounMin Won Lee
Feb 18, 2011·Urologia Internationalis·Yiwei LinLiping Xie
Dec 19, 2009·Scandinavian Journal of Urology and Nephrology·Kuang-Chi LaiWen-Chi Chen
Aug 28, 2021·Cells·Paulina WignerJoanna Saluk-Bijak

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