Association of Kawasaki disease with tropospheric winds in Central Chile: is wind-borne desert dust a risk factor?

Environment International
Héctor JorqueraAlvaro García

Abstract

It has been found that Kawasaki disease (KD) cases diagnosed in Japan, Hawaii and San Diego, USA increase when tropospheric wind patterns arrive from central Asia, suggesting a common, wind-borne causal agent. We analyzed KD cases hospitalized in Santiago, Chile to look for associations with local, regional and large scale meteorological variables. We compiled monthly data of KD incidence rates, local meteorological variables, large scale wind patterns and several El Niño Southern Oscillation (ENSO) indices for 2001-2010; we considered standardized anomalies in all analyses and used linear time series models to account for data autocorrelation. We found that meteorological variables explain 38% of variance in KD rates. A unit increase in northerly wind at 3 lagged months, temperature at 1 and 3 lagged months and monthly change of ENSO 4 index are associated with changes in KD rates of 0.203 (95% CI 0.049-0.358), 0.181 (95% CI 0.014-0.347), 0.192 (95% CI 0.030-0.353) and -0.307 (95% CI -0.458-0.156), respectively. These results are robust when northerly wind level is changed or when a shorter period (2005-2010) is used to estimate model parameters. We found a statistical association of KD at Santiago, Chile with tropospheric, no...Continue Reading

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Citations

Jun 27, 2015·Archives of Disease in Childhood·Surjit SinghDavid Burgner
May 31, 2018·Rheumatology International·Leyre Riancho-ZarrabeitiaAna Santurtún
Mar 4, 2020·International Journal of Environmental Research and Public Health·Elena CorinaldesiMarcello Lanari
Apr 21, 2019·Medical Sciences : Open Access Journal·Maryam BehmadiAbdolreza Malek
Sep 15, 2020·Current Rheumatology Reports·Eileen Rife, Abraham Gedalia
Mar 17, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mindy S Lo

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