Association of Kidney Transplantation with Survival in Patients with Long Dialysis Exposure

Clinical Journal of the American Society of Nephrology : CJASN
C RoseJ S Gill

Abstract

Evidence that kidney transplantation is associated with better survival compared to dialysis stems from data in populations with short durations of dialysis exposure. Recent changes in allocation policy increase access to transplantation for patients with longer dialysis exposure. The objective of this study was to determine the association of transplantation with survival in patients with ≥10 years of dialysis treatment. Our study of n=5365 patients in the Scientific Registry of Transplant Recipients determined the adjusted relative risk of death in recipients of a deceased donor kidney transplant after ≥10 years of dialysis treatment compared with waitlisted patients with the same dialysis exposure in a time-dependent nonproportional hazards analysis. The adjusted relative risk of death in n=2320 transplant recipients compared with patients on dialysis who had equal lengths of follow-up from their 10-year dialysis anniversary was 0.60 (95% confidence interval, 0.53 to 0.68), and this benefit was observed in a variety of patient subgroups, including patients ≥65 years of age and patients with diabetes. However, transplant recipients were at higher risk of death for 180 days after transplantation and did not derive survival ben...Continue Reading

References

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Citations

Jul 19, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jesse D ScholdEmilio D Poggio
Apr 24, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Denis GlotzUNKNOWN C10-002 Study Group
Mar 20, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Meera N HarhayMara A McAdams-DeMarco
Jun 2, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Sandesh ParajuliDidier A Mandelbrot
Jan 21, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Abdulhak Hamit KarayagizIbrahim Berber
Dec 22, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emilio D PoggioJesse D Schold
Mar 28, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Florence RunyoGiovanna Melica
Jun 10, 2021·Cadernos de saúde pública·Francisca Maria Rodrigues Dos SantosTainá Veras de Sandes-Freitas
Sep 10, 2021·Anesthesiology·Duminda N Wijeysundera, Stuart A McCluskey
Jul 1, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Piyavadee Homkrailas, Suphamai Bunnapradist
Nov 24, 2021·International Urology and Nephrology·Charalampos LoutradisGeorgios A Pitoulias
Mar 24, 2021·Transplantation·Jennifer LiNatasha M Rogers

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