Association of lamotrigine and valproate in refractory epilepsies of children and adolescents

Arquivos de neuro-psiquiatria
Karen P GrisottoLúcia H C Santos


To evaluate the efficacy or eventual side-effects of the association of lamotrigine and sodium valproate in the control of refractory epilepsies. A retrospective analysis of 37 children with a mean age of 12 years taking exclusively lamotrigine and sodium valproate. Efficacy of seizure control was considered satisfactory if there was a reduction in seizures>50% or total control. The association of lamotrigine and sodium valproate was considered satisfactory in 65% of the studied children, independent of seizure type. Total seizure control was obtained in 33% and 35% had an unsatisfactory response or remained unchanged. Primary generalized tonic clonic seizures were the most common type with 84% of day-time seizures having a good response to treatment. Side-effects were seen in 11% of patients and the most common was tremor. Total or satisfactory control of seizures was seen in the majority of patients and side-effects were uncommon.


Nov 12, 1994·Lancet·P VeggiottiO Dulac
Jun 1, 1994·Seizure : the Journal of the British Epilepsy Association·C D Ferrie, C P Panayiotopoulos
Feb 13, 1993·Lancet·C P PanayiotopoulosR O Robinson
May 8, 1993·Lancet·F PisaniA Richens
Apr 12, 2002·Seizure : the Journal of the British Epilepsy Association·Patrick Kwan, Martin J Brodie
Sep 28, 2002·Therapeutic Drug Monitoring·Mihaela-Irina MataringaBernhard Rambeck
Jul 25, 2003·Pediatric Neurology·Sigride Thomé-SouzaKette D Valente
Apr 19, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R Mohanraj, M J Brodie

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May 15, 2013·Pediatric Neurology·Sigride Thome-Souza, Kette D Valente

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