Association of left ventricular dilation at listing for heart transplant with postlisting and early posttransplant mortality in children with dilated cardiomyopathy

Circulation. Heart Failure
Tajinder P SinghSteven Colan

Abstract

In patients with dilated cardiomyopathy, the magnitude of cardiac remodeling often correlates with the clinical severity of heart failure. We sought to determine whether measures of left ventricular (LV) dilation and systolic dysfunction in children with dilated cardiomyopathy at the time of listing for cardiac transplantation are associated with survival while waiting for and early after transplant. We analyzed echocardiographic data obtained within 6 months of listing for heart transplant and clinical data from 261 children with dilated cardiomyopathy who were included in both the Pediatric Cardiomyopathy Registry and the Pediatric Heart Transplant Study. Median time to listing after diagnosis was 1.9 months and to transplant after listing was 0.8 months. There were 42 deaths (29 waiting and 13 within 6 months after transplant). We found a significant age-dependent association of LV end-diastolic dimension z score (n=204, 31 deaths) with death controlling for race, transplant status, and medical insurance. The association was strongest for infants younger than 6 months at diagnosis (hazard ratio 1.47, P=0.008) and was not significant in children older than 5 years at diagnosis. A similar interaction was identified between age...Continue Reading

References

Mar 1, 1992·Journal of the American College of Cardiology·S D ColanS P Sanders
Sep 15, 1993·The American Journal of Cardiology·T H LeeJ A Walden
Feb 25, 1999·The New England Journal of Medicine·D L DriesM J Domanski
Nov 14, 2002·Physiological Genomics·M SteenmanJ J Léger
Mar 5, 2004·Journal of the American College of Cardiology·Javed ButlerJohn R Wilson
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer HuangCharles E Canter
Nov 24, 2004·Journal of Applied Physiology·Thierry Sluysmans, Steven D Colan
Dec 17, 2005·The Journal of Pediatrics·William T MahleRobert N Vincent
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Jeffrey A TowbinSteven E Lipshultz
Nov 23, 2006·Circulation·Piers E F DaubeneyUNKNOWN National Australian Childhood Cardiomyopathy Study
Jul 4, 2007·Circulation·Thomas ThumJohann Bauersachs
Apr 2, 2008·Congenital Heart Disease·Daphne T HsuJames K Kirklin
Sep 4, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkMarshall I Hertz
Sep 1, 2007·Progress in Pediatric Cardiology·Jorge A AlvarezSteven E Lipshultz

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Citations

Mar 31, 2011·Pediatric Cardiology·Jack Christian SalernoDavid Michael McMullan
Jul 27, 2011·Circulation·Jorge A AlvarezUNKNOWN Pediatric Cardiomyopathy Registry Investigators
Feb 16, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dietmar SchranzHakan Akintürk
Sep 28, 2010·Heart Failure Clinics·Daphne T Hsu, Charles E Canter
Nov 29, 2011·European Journal of Heart Failure·Yaron GorenOffer Amir
Sep 18, 2015·Cardiology in the Young·James D WilkinsonSteven E Lipshultz
Feb 25, 2014·Journal of the American College of Cardiology·Melanie D EverittUNKNOWN Pediatric Cardiomyopathy Registry Investigators
Oct 18, 2013·Circulation. Heart Failure·Kimberly M MolinaUNKNOWN Pediatric Heart Network Investigators
Nov 13, 2013·Expert Review of Cardiovascular Therapy·Brian F BirnbaumCharles E Canter
Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Komarakshi Rajagopalan BalakrishnanDhruva Sharma
Dec 22, 2020·The Canadian Journal of Cardiology·Ryo IshiiMark K Friedberg

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