Association of leisure time physical activity and NMR-detected circulating amino acids in peripubertal girls: A 7.5-year longitudinal study

Scientific Reports
Xiaobo ZhangSulin Cheng

Abstract

This study investigated the longitudinal associations of physical activity and circulating amino acids concentration in peripubertal girls. Three hundred ninety-six Finnish girls participated in the longitudinal study from childhood (mean age 11.2 years) to early adulthood (mean age 18.2 years). Circulating amino acids were assessed by nuclear magnetic resonance spectroscopy. LTPA was assessed by self-administered questionnaire. We found that isoleucine, leucine and tyrosine levels were significantly higher in individuals with lower LTPA than their peers at age 11 (p < 0.05 for all), independent of BMI. In addition, isoleucine and leucine levels increased significantly (~15%) from childhood to early adulthood among the individuals with consistently low LTPA (p < 0.05 for both), while among the individuals with consistently high LTPA the level of these amino acids remained virtually unchanged. In conclusion, high level of physical activity is associated lower serum isoleucine and leucine in peripubertal girls, independent of BMI, which may serve as a mechanistic link between high level of physical activity in childhood and its health benefits later in life. Further studies in peripubertal boys are needed to assess whether associ...Continue Reading

References

Sep 1, 1977·Endocrinology·A R Glass, R S Swerdloff
Mar 1, 1986·Annals of Human Biology·H Goldstein
Oct 9, 1969·The New England Journal of Medicine·P FeligG F Cahill
May 18, 2001·Archives of Pediatrics & Adolescent Medicine·J J ProchaskaB Long
Jun 5, 2003·British Journal of Sports Medicine·R J Shephard
Jun 3, 2005·The Journal of Nutrition·Robert A HarrisMariko Obayashi
Mar 24, 2009·Exercise and Sport Sciences Reviews·Edward L MelansonJames O Hill
Nov 26, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eszter VölgyiSulin Cheng
Feb 6, 2010·Journal of Applied Physiology·Pengxiang SheChristopher J Lynch
Dec 24, 2010·Molecular Systems Biology·Michael InouyeLeena Peltonen
Feb 19, 2011·Journal of Applied Physiology·Eszter VölgyiSulin Cheng
Jul 28, 2011·British Journal of Sports Medicine·Lars Bo AndersenAndrew Hills
Dec 14, 2011·Human Molecular Genetics·Taru TukiainenSamuli Ripatti
May 9, 2012·Diabetes Care·Peter WürtzMika Ala-Korpela
May 29, 2012·Revista Española De Cardiología·Alfredo CordovaMaría P Sánchez-Collado
Dec 18, 2012·European Heart Journal·Martin MagnussonOlle Melander
Dec 22, 2012·Circulation·Urho M KujalaMika Ala-Korpela
Jul 23, 2013·Exercise and Sport Sciences Reviews·Heikki KainulainenUrho M Kujala
Dec 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Bryan C BatchLaura P Svetkey
Mar 12, 2016·The Journal of Clinical Endocrinology and Metabolism·Petri WiklundSulin Cheng
Apr 14, 2016·International Journal of Epidemiology·Qian XiaoCharles E Matthews
Aug 1, 2016·Lancet·Ding DingUNKNOWN Lancet Physical Activity Series 2 Executive Committee
May 26, 2017·The Journal of Physiology·Corey A RyndersAudrey Bergouignan
May 27, 2017·Journal of Applied Physiology·Sune DandanellJørn Wulff Helge

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Methods Mentioned

BETA
NMR

Software Mentioned

MLwiN
SPSS Statistics

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