Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).

Clinical Interventions in Aging
Thomas O ObisesanRichard F Gillum

Abstract

To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups. Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988-1994). US noninstitutionalized population. From a sample of 7159, aged ≥60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus. In the initial bivariate analysis, non-ɛ4 carriers and ɛ4-heterozygotes performed better than ɛ4-homozygotes in the 60-69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-ɛ4 carriers (P = 0.014), but not in ɛ4 carriers (P = 0.887). At ≥70 years, PA also correlated with higher adjusted SMSE scores in non-ɛ4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12). In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. ...Continue Reading

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Nov 7, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carrington R WendellAlan B Zonderman
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Jan 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Eric R YooAijaz Ahmed
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Mar 20, 2019·European Journal of Gastroenterology & Hepatology·Karn WijarnpreechaAijaz Ahmed
Mar 1, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Donghee KimAijaz Ahmed

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