Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of Rheumatoid arthritis: a case control study

Journal of Translational Medicine
Stefan ReichertSusanne Schulz

Abstract

Periodontal disease could be a risk factor for rheumatoid arthritis (RA). It is assumed that the bacterial strain Porphyromonas gingivalis mediates citrullination of host peptides and thereby the generation of RA-associated autoantibodies in genetically predisposed individuals. For that reason non-RA individuals who suffered from generalized aggressive (GAgP, N = 51) and generalized chronic periodontitis (GChP, N = 50) were investigated regarding the occurrence of antibodies against citrullinated cyclic peptides (anti-CCP) and citrullinated α-enolase peptide-1 (anti-CEP-1) in comparison to non-RA non-periodontitis controls (N = 89). Furthermore, putative associations between infections with five periodontopathic bacteria or expression of certain human leucocyte antigens (HLA) to these autoantibodies were investigated. The presence of anti-CCP and anti-CEP-1 in plasma samples was conducted with enzyme linked immunosorbent assay. Subgingival plaque specimens were taken from the deepest pocket of each quadrant and pooled. For detection of DNA of five periodontopathic bacteria PCR with sequence specific oligonucleotides was carried out. Low resolution HLA typing was carried out with PCR with sequence specific primers. Differences b...Continue Reading

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Mar 29, 2013·Journal of Clinical Periodontology·Stefan ReichertSusanne Schulz
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Citations

Aug 25, 2017·Nature Reviews. Rheumatology·Jan PotempaJoanna Koziel
Apr 11, 2020·Journal of Clinical Medicine·Natalia Mena-VázquezAntonio Fernández-Nebro
May 10, 2020·Periodontology 2000·Peter Mark Bartold, Isabel Lopez-Oliva
Nov 23, 2019·Molecular & Cellular Proteomics : MCP·Daniel Nyberg LarsenPeter Højrup
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Daniel Nyberg LarsenPeter Højrup
Oct 17, 2020·Journal of Translational Medicine·Susanne SchulzStefan Reichert

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Methods Mentioned

BETA
enzyme linked immunsorbent assay
PCR
electrophoresis

Software Mentioned

SPSS

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