PMID: 11917194Mar 28, 2002Paper

Association of lipids, lipoproteins, apolipoproteins and paraoxonase enzyme activity with premature coronary artery disease

Coronary Artery Disease
Fereidoun AziziMohammad Navab

Abstract

The association of serum apolipoprotein (apo) A-I and apo B concentrations and paraoxonase (PON) enzyme activity with angiographically determined coronary artery disease (CAD) was investigated in Iranian non-diabetic patients with premature CAD and control participants in a sex- and age-matched case-control study. The study population consisted of 59 non-diabetic patients with premature CAD and 55 CAD control participants. Premature CAD was defined as the presence of angiographically proven coronary stenosis (> or =50% involvement) in men and women younger than 55 and 65 years, respectively. Apolipoprotein concentrations were measured by immunoturbidometric assay and paraoxonase/arylesterase activities by spectrophotometric assay of p-nitrophenol/phenol production following addition of paraoxon/phenylacetate to serum. In CAD patients, increased concentrations of total cholesterol (215 +/- 43 compared with 193 +/- 43, P < 0.001), low-density lipoprotein cholesterol (137 +/- 46 compared with 116 +/- 39, P < 0.05) and apo B (102 +/- 24 compared with 84 +/- 17, P < 0.001) and a decreased ratio of apo A-I/apo B (1.7 +/- 0.4 compared with 2.0 +/- 0.6, P < 0.001) were observed compared to the control group. Other study variables were ...Continue Reading

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Citations

Oct 1, 2012·Journal of Nephropathology·Mehrdad Solati, Hamid-Reza Mahboobi
Dec 18, 2003·Clinical Endocrinology·Farbod RaiszadehFereidoun Azizi
Jul 27, 2007·Basic & Clinical Pharmacology & Toxicology·Farideh SepahvandMassoud Mahmoudian
Feb 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M SolatiF Azizi
Feb 11, 2021·Antioxidants·Giuseppe MancoTeresa Maria Carusone
Jun 29, 2021·International Journal of Clinical Practice·Mohammad Haji AghajaniMahmoud Yousefifard

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