Association of lipoprotein lipase gene polymorphism with risk of prostate cancer in a Japanese population

International Journal of Cancer. Journal International Du Cancer
Shintaro NaritaTetsuro Kato

Abstract

A high fat intake has been associated with prostate cancer risk, and gene polymorphisms of lipoprotein lipase (LPL) play an important role in plasma lipoprotein metabolism. We herein analyzed the association of LPL gene polymorphisms with the risk of prostate cancer in a Japanese population. Three single nucleotide polymorphisms (SNPs) of LPL designated as Ser447stop, HindIII and PvuII were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method in 273 prostate cancer patients, 205 benign prostatic hyperplasia (BPH) patients and 230 male controls. The men with the CG + GG genotypes of the Ser447stop polymorphism had an increased risk of prostate cancer compared to those with the CC genotype [age-adjusted odds ratio (aOR) = 1.625; 95% CI = 1.068-2.471; p = 0.023]. Furthermore, the increased risk associated with the CG + GG genotypes was more strongly observed in patients with high-grade cancers (aOR = 2.843; 95% CI = 1.252-6.458; p = 0.039) or metastatic diseases (aOR = 2.300; 95% CI = 1.042-5.074; p = 0.013), whereas the risk was not significant in those with low- to intermediate-grade cancers or nonmetastatic diseases. In the HindIII and PvuII polymorphisms, there was no significant differenc...Continue Reading

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Citations

Oct 27, 2011·Biochemistry Research International·Shinji TakasuHitoshi Nakagama
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Jin Woo KimBao-Li Chang
Jul 13, 2006·BJU International·Seval Yildiz-SezerGregor Mikuz
Sep 2, 2006·Critical Reviews in Oncology/hematology·H G van der Poel
Apr 14, 2015·BioMed Research International·Seher BalabanAndrew J Hoy
Apr 1, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jaap RipJan Albert Kuivenhoven
Aug 18, 2020·European Journal of Clinical Nutrition·Toon J I De MunckGer H Koek
Mar 10, 2007·Molecular Biology Reports·Jizhong LuShengdong Huang
Oct 31, 2006·World Journal of Gastroenterology : WJG·Toshihito KosakaTakahiko Katoh

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