Association of Lipoprotein(a) With Risk of Recurrent Ischemic Events Following Acute Coronary Syndrome: Analysis of the dal-Outcomes Randomized Clinical Trial

JAMA Cardiology
Gregory G SchwartzJohn Kittelson

Abstract

It is uncertain whether lipoprotein(a) [Lp(a)], which is associated with incident cardiovascular disease, is an independent risk factor for recurrent cardiovascular events after acute coronary syndrome (ACS). To determine the association of Lp(a) concentration measured after ACS with the subsequent risk of ischemic cardiovascular events. This nested case-cohort analysis was performed as an ad hoc analysis of the dal-Outcomes randomized clinical trial. This trial compared dalcetrapib, the cholesteryl ester transfer protein inhibitor, with placebo in patients with recent ACS and was performed between April 2008 and September 2012 at 935 sites in 27 countries. There were 969 case patients who experienced a primary cardiovascular outcome, and there were 3170 control patients who were event free at the time of a case event and had the same type of index ACS (unstable angina or myocardial infarction) as that of the respective case patients. Concentration of Lp(a) was measured by immunoturbidimetric assay. Data analysis for this present study was conducted from June 8, 2016, to April 21, 2017. Patients were randomly assigned to receive treatment with dalcetrapib, 600 mg daily, or matching placebo, beginning 4 to 12 weeks after ACS. De...Continue Reading

Citations

Feb 6, 2019·Current Opinion in Lipidology·Ernst J SchaeferGregory Endress
Apr 3, 2019·European Journal of Clinical Investigation·Baris GencerFrançois Mach
Mar 8, 2020·Diabetes Care·Gregory G SchwartzJohn Kittelson
Jun 16, 2018·European Heart Journal·Ulf Landmesser, Stan Hazen
Mar 28, 2019·Expert Review of Cardiovascular Therapy·Katrina L EllisGerald F Watts
Jan 5, 2019·European Heart Journal·Anne LangstedBørge G Nordestgaard
Jan 25, 2019·Nature Reviews. Cardiology·Michael B Boffa, Marlys L Koschinsky
Apr 21, 2020·Vascular Health and Risk Management·I Dewa Gde Dwi SumarjayaAnak Agung Wiradewi Lestari
Dec 18, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Federico BigazziTiziana Sampietro
May 12, 2021·European Journal of Internal Medicine·Peter WohlfahrtJosef Kautzner
Jul 15, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Venner EricUNKNOWN eMERGE Consortium
Jul 9, 2021·Current Atherosclerosis Reports·David RhaindsJean-Claude Tardif
Aug 15, 2021·European Journal of Preventive Cardiology·Ioannis ParthymosMatilda Florentin
Sep 11, 2021·The American Journal of Cardiology·Gennaro GalassoCarmine Vecchione

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