Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease

Investigative Ophthalmology & Visual Science
Yingying YueShengping Hou

Abstract

Long noncoding RNAs (lncRNAs) are emerging as important regulators of inflammatory immune responses, whereby genetic variants may affect this biologic function. This study aimed to investigate the association of 110 single nucleotide polymorphisms (SNPs) of lncRNAs, known to be associated with autoimmune disease, in patients with ocular Vogt-Koyanagi-Harada (VKH) disease, Behcet's disease (BD), and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS). A two-stage case-control study was performed on 1626 VKH patients, 384 BD patients, 624 AAU with AS, 751 AAU without AS, 720 AS without AAU, and 3305 healthy subjects. lncRNAs 110 SNPs were genotyped using MassARRAY System or TaqMan SNP assays. The gene expression and cytokine production were measured using real-time PCR or ELISA. The frequency of the C allele of rs4937362 in RP11-264E20.1 was markedly decreased in the AS without AAU group compared with controls (Combined P = 9.37 × 10-7, odds ratio [OR] = 0.73). An increased frequency of the A allele of rs6871626 between UBLCP1, IL12B, and LOC285627 was found in VKH patients compared with controls (Combined P = 1.88 × 10-4, OR = 1.19). UBLCP1, IL12B, and LOC285627 were expressed in human uveal tissues. Functio...Continue Reading

Citations

Jul 18, 2018·International Journal of Oncology·Huaying DongJing Han
Sep 26, 2020·International Ophthalmology·Alia M Albalawi, Maan A Al-Barry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.