Association of Long-term Opioid Therapy With Functional Status, Adverse Outcomes, and Mortality Among Patients With Polyneuropathy

JAMA Neurology
E Matthew HoffmanChristopher J Klein

Abstract

Polyneuropathy is one of the most common painful conditions managed within general and specialty clinics. Neuropathic pain frequently leads to decisions about using long-term opioid therapy. Understanding the association of long-term opioid use with functional status, adverse outcomes, and mortality among patients with polyneuropathy could influence disease-specific decisions about opioid treatment. To quantify the prevalence of long-term opioid use among patients with polyneuropathy and to assess the association of long-term opioid use with functional status, adverse outcomes, and mortality. A retrospective population-based cohort study was conducted of prescriptions given to patients with polyneuropathy and to controls in ambulatory practice between January 1, 2006, and December 31, 2010, to determine exposure to long-term opioid use as well as other outcomes. The latest follow-up was conducted through November 25, 2016. Long-term opioid therapy, defined by 1 or multiple consecutive opioid prescriptions resulting in 90 continuous days or more of opioid use. Prevalence of long-term opioid therapy among patients with polyneuropathy and controls. Patient-reported functional status, documented adverse outcomes, and mortality were...Continue Reading

Citations

Apr 5, 2018·Current Pain and Headache Reports·Alan David KayeKenneth F Mancuso
Feb 14, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Arya ShahNathan P Staff
Jun 16, 2018·Pain·Graham MazereeuwDavid N Juurlink
Oct 1, 2018·Pain Practice : the Official Journal of World Institute of Pain·Lindsay A DiMarcoChad E Cook
Feb 27, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Natalia BienekChristine H Meyer-Frießem
Jul 22, 2017·Nature Reviews. Neurology·Claudia Sommer
Jul 25, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jessica C YoungNabarun Dasgupta
Jul 13, 2019·Pain·Suzanne M Green-FulghamPeter M Grace
Jul 20, 2019·Journal of Alzheimer's Disease : JAD·Christina Jensen-DahmGunhild Waldemar
Sep 19, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Min XuChristopher J Klein
Aug 18, 2020·Current Pain and Headache Reports·Alex Jinich-DiamantFadel Zeidan
Jan 6, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mark Sullivan
Jan 25, 2020·Diabetologia·Brian C CallaghanEva L Feldman
Sep 11, 2020·Journal of General Internal Medicine·Laura G MilitelloChristopher A Harle
Jul 31, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Shuai ZhaoYuan Zhang
Apr 27, 2019·Frontiers in Pharmacology·Mihály BaloghMahmoud Al-Khrasani
Jun 17, 2020·Journal of Psychiatry and Brain Science·Jeffrey F ScherrerSarah Skiold-Hanlin
Jan 19, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David J DiBenedettoJianren Mao
Sep 15, 2020·Current Sports Medicine Reports·William H WestChristopher R Gordon
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susanna FürstMahmoud Al-Khrasani
Nov 13, 2020·Pharmacology & Therapeutics·Vipin AroraMan-Kyo Chung
Oct 9, 2020·The Journal of Pain : Official Journal of the American Pain Society·Yun ShenAmie J Goodin
Feb 26, 2021·British Journal of Clinical Pharmacology·Juliana de Oliveira CostaSallie-Anne Pearson
Apr 17, 2021·Clinics in Geriatric Medicine·Lan Zhou
Apr 23, 2021·Alzheimer's Research & Therapy·Yu-Jung Jenny WeiAlmut G Winterstein
Apr 20, 2021·Frontiers in Medicine·Dokyoung S YouSean C Mackey
Nov 7, 2021·Neuromolecular Medicine·Barira IslamPatrick C McHugh
Oct 29, 2021·Neurology·Stephen A JohnsonChristopher J Klein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.