Association of longitudinal measures of hemoglobin and outcomes after hospitalization for heart failure

American Heart Journal
Pamela N PetersonFrederick A Masoudi

Abstract

Cross-sectional assessments of hemoglobin (Hb) are associated with mortality in patients with heart failure (HF). Our objectives were to characterize patterns of change in Hb over time in patients with HF and to evaluate the relationship between longitudinal measures of Hb and adverse outcomes. The study included 2,478 patients with a primary discharge diagnosis of HF from January 2001 to December 2006. Outcomes included time to death and time to death or HF hospitalization. The association between baseline Hb and outcomes was evaluated using multivariable Cox regression. The longitudinal association was evaluated using a time-dependent Hb predictor variable and using anemia trajectory groups. For a median of 475 days, baseline Hb was associated with a trend toward increased mortality (hazard ratio [HR] 1.02, 95% CI 0.99-1.06 per g/dL decline). With a time-dependent approach, the magnitude of the association was greater (HR 1.35, 95% CI 1.30-1.39 per g/dL decline). In trajectory analysis, 35% of the cohort had variable patterns of anemia. Persistently low Hb (HR 1.65, 95% CI 1.27-2.14) and a progressive decline in Hb (HR 1.54, 95% CI 1.16-2.05) were associated with increased mortality risk. Patients with recovery of anemia had ...Continue Reading

References

Jan 22, 2003·Journal of the American College of Cardiology·Frederick A MasoudiHarlan M Krumholz
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Oct 24, 2007·Journal of the American College of Cardiology·Jorge Eduardo ToblliFederico Di Gennaro
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Jun 10, 2008·European Journal of Heart Failure·Thomas KümlerChristian Torp-Pedersen
Aug 12, 2008·The American Journal of Medicine·Shannon M DunlayVéronique L Roger

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Citations

Sep 4, 2012·Current Heart Failure Reports·Shanti Gunawardena, Mark E Dunlap
Dec 22, 2011·British Journal of Anaesthesia·A ShanderG M T Hare
Jun 17, 2014·Transfusion Medicine Reviews·Aryeh ShanderIndu Lew
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Gregory M T HareAryeh Shander
May 31, 2011·Revista clínica española·J Grau-AmorósUNKNOWN del Grupo de Trabajo de la Insuficiencia Cardiaca de la SEMI
Jul 16, 2010·Heart Failure Clinics·W H Wilson Tang, P S Daniel Yeo
Jul 16, 2010·Heart Failure Clinics·Inder S Anand
Jul 16, 2010·Heart Failure Clinics·Adam C Salisbury, Mikhail Kosiborod
Oct 26, 2016·American Journal of Hematology·Lawrence Tim GoodnoughAryeh Shander
May 23, 2013·Internal Medicine Journal·A D PisanielloS Shakib
Oct 30, 2019·BMC Public Health·Alimu DayimuFuzhong Xue
Nov 9, 2019·Journal of the American Heart Association·Kazuya NagaoUNKNOWN CREDO‐Kyoto PCI/CABG Registry Cohort‐2, RESET, and NEXT Investigators
May 9, 2021·Medicina clínica·Jordi Grau AmorósUNKNOWN en representación de los investigadores del Grupo RICA

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