Association of loss of muscle mass with mortality in liver cirrhosis without or before liver transplantation: A systematic review and meta-analysis

Medicine
Ke-Vin ChangDer-Sheng Han

Abstract

Liver cirrhosis is a risk factor for the loss of muscle mass, which is associated with numerous adverse health outcomes. This meta-analysis aimed to examine whether loss of muscle mass was a predictor of increased mortality in cirrhotic patients without or before liver transplantation. Without language restriction, PubMed and Embase were searched for articles published from the earliest records to December 2018 investigating the influence of loss of muscle mass on survival of cirrhotic patients. Those who had undergone liver transplantation and had hepatocellular carcinoma were excluded. The main outcome was the hazard ratio (HR) for the association of mortality with loss of muscle mass, and the secondary outcome was the association of loss of muscle mass with Child-Pugh class and death caused by severe infection. The meta-analysis included 16 observational studies, comprising 4070 participants. The pooled crude and adjusted HRs for the association of mortality with loss of muscle mass were 2.05 (95% confidence interval [CI], 1.51-2.78) and 2.36 (95% CI, 1.61-3.46). Using Child-Pugh Class A as reference, the odds ratios (ORs) for the association of loss of muscle mass with Child-Pugh Class B and Class C were 1.68 (95% CI, 0.96-...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Apr 25, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Teh-Ia HuoHan-Chieh Lin
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Feb 12, 2011·BMJ : British Medical Journal·Richard D RileyJonathan J Deeks
Sep 7, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aldo J Montano-LozaMichael B Sawyer
Jun 29, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Puneeta TandonRobert P Myers
Jan 28, 2014·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
Mar 15, 2014·World Journal of Gastroenterology : WJG·Nora SipekiMaria Papp
Mar 29, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Aldo J Montano-LozaNorman Kneteman
Aug 26, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ronan Thibault, Laurence Genton
Sep 24, 2014·Journal of Korean Medical Science·Tae Yeob KimYoungsoo Kim
Dec 3, 2014·Nutrition·Tatsunori HanaiHisataka Moriwaki
Jul 4, 2015·World Journal of Gastroenterology : WJG·Maria KalafateliChristos Triantos
Jul 15, 2015·World Journal of Gastroenterology : WJG·Hee Yeon Kim, Jeong Won Jang
Jul 17, 2015·Clinical and Translational Gastroenterology·Aldo J Montano-LozaRobert P Myers
Aug 16, 2015·BMJ : British Medical Journal·Philip Sedgwick
Sep 29, 2015·Journal of Gastroenterology and Hepatology·Marie SinclairPaul J Gow
Nov 19, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsunori HanaiMasahito Shimizu
Dec 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yong-ho LeeKwang-Hyub Han
Feb 5, 2016·Worldviews on Evidence-based Nursing·Shu-Fang Chang, Pei-Ling Lin
Feb 6, 2016·Alimentary Pharmacology & Therapeutics·M SinclairP W Angus
Feb 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shlomit Strulov ShacharTomohiro F Nishijima
Aug 6, 2016·Journal of Cachexia, Sarcopenia and Muscle·Aldo J Montano-LozaVickie E Baracos
Nov 7, 2016·Journal of the American Medical Directors Association·Ke-Vin ChangDer-Sheng Han
Nov 7, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Silvia NardelliOliviero Riggio
Jan 18, 2017·PloS One·Charlotte BeaudartOlivier Bruyère
Feb 16, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsunori HanaiMasahito Shimizu
Apr 14, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Giliane BelarminoDan L Waitzberg
Jun 20, 2017·Journal of Cachexia, Sarcopenia and Muscle·Hiroki NishikawaShuhei Nishiguchi
Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael PraktiknjoJonel Trebicka
Oct 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Jaya BenjaminShiv Kumar Sarin
Jan 13, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Cristina LucidiManuela Merli
Jun 9, 2018·Hepatology International·Rahima A BhanjiAldo J Montano-Loza
Oct 1, 2018·Journal of Cachexia, Sarcopenia and Muscle·Maryam EbadiUNKNOWN From the Fitness, Life Enhancement, and Exercise in Liver Transplantation (FLEXIT) Consortium
Oct 30, 2018·Journal of Cachexia, Sarcopenia and Muscle·Seong Hee KangMoon Young Kim

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BETA
X-ray

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Comprehensive Meta - analysis Software

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