Association of low 25-hydroxyvitamin D levels with the frailty syndrome in an aged population: results from the KORA-age Augsburg study

The Journal of Nutrition, Health & Aging
G PabstBarbara Thorand

Abstract

Older adults often suffer from vitamin D deficiency and from the frailty syndrome charac-terized by different physical limitations, complicating independent everyday life. Previous studies have suggested a relationship between vitamin D status and the frailty syndrome, but results have been partly inconsistent, particularly regarding the shape of the association. Therefore, our aim was to further assess the association of 25-hydroxyvitamin D (25(OH)D) serum levels and frailty in older participants. Cross-sectional population-based study. The study population included 478 men and 462 women of the KORA (COoperative health research in the Region of Augsburg)-Age study born before 1944 examined in 2009. Classification of participants into different frailty states was performed according to the following criteria: weight loss, exhaustion, physical inactivity, slowness, and weakness. PARTICIPANTS who met 1-2 or ≥ 3 of the 5 criteria were classified as prefrail or frail, respectively. Total 25(OH)D was measured in non-fasting serum samples with an enhanced chemiluminescence immunoassay. Sequential logistic regression models adjusted for age, sex, season, lifestyle factors, diseases and biomarkers including parathyroid hormone (PTH) we...Continue Reading

References

Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Apr 1, 1996·The Journal of Nutrition·M F Holick
Apr 10, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H Scharla
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A B NewmanUNKNOWN Cardiovascular Health Study Research Group
Mar 28, 2002·The American Journal of Clinical Nutrition·Hennie C J P JanssenHarald J J Verhaar
Oct 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E MorleyDouglas K Miller
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Marjolein VisserUNKNOWN Longitudinal Aging Study Amsterdam
Mar 17, 2004·The Proceedings of the Nutrition Society·Lars OvesenJette Jakobsen
Mar 18, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·A LarssonL O Hansson
Jul 21, 2005·Das Gesundheitswesen·H LöwelUNKNOWN MONICA/KORA Study Group
Jul 21, 2005·Das Gesundheitswesen·R HolleUNKNOWN MONICA/KORA Study Group
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Marieke B SnijderPaul Lips
Sep 12, 2006·The Medical Clinics of North America·John E MorleyMoon Jong Kim
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A StevensAndrew S Levey
Aug 30, 2008·Molecular Aspects of Medicine·Lisa Ceglia
Jan 24, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Jun 10, 2010·Journal of Internal Medicine·E R Wilhelm-LeenG M Chertow
Aug 5, 2010·Biogerontology·W J EvansF Lattanzio
Dec 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Clifford J Rosen, JoAnn E Manson
Dec 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Jan 14, 2011·Journal of the American Geriatrics Society·Kristine E EnsrudUNKNOWN Osteoporotic Fractures in Men Study Group
Apr 30, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Cynthia Aranow
Feb 1, 2012·Zeitschrift für Gerontologie und Geriatrie·A PetersR Holle
Aug 25, 2012·Journal of Aging Research·Kaitlyn P RolandGareth R Jones
May 10, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Vasant HiraniMarkus J Seibel
Feb 26, 2014·The Journal of Clinical Endocrinology and Metabolism·Hamimatunnisa JoharKarl-Heinz Ladwig
Jun 3, 2014·The Journal of Nutrition, Health & Aging·S SchwabB Thorand

❮ Previous
Next ❯

Citations

Dec 17, 2015·Zeitschrift für Gerontologie und Geriatrie·Judith FuchsEva Grill
Dec 23, 2016·Journal of the American Geriatrics Society·Brian ButaRita Rastogi Kalyani
Apr 25, 2018·European Journal of Nutrition·Anouk M M VaesLisette C P G M de Groot
Nov 16, 2018·Aging & Mental Health·Karen S van den BergRichard C Oude Voshaar
Oct 2, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Vicky Kamwa, Zaki K Hassan-Smith
Feb 13, 2020·Geriatrics & Gerontology International·Masafumi KuzuyaHidenori Arai
Jan 24, 2017·The Journal of Nutrition, Health & Aging·C TrevisanG Sergi
Aug 7, 2020·Revista brasileira de enfermagem·Fabiana Maria Rodrigues Lopes de OliveiraMaria das Graças Melo Fernandes
Nov 22, 2019·Experimental Gerontology·Riccardo CalvaniUNKNOWN European MID-Frail Consortium
Apr 18, 2017·Soins. Gérontologie·Mathilde NicolasÉmilie Crawford-Achour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.