Association of Low Birth Weight With Altered Corneal Geometry and Axial Length in Adulthood in the German Gutenberg Health Study

JAMA Ophthalmology
Achim FießNorbert Pfeiffer

Abstract

Low birth weight is associated with altered ocular organ development in childhood, including the morphology of the eye. However, no population-based data exist about this association in adulthood. To evaluate whether low birth weight has a long-term association with anterior segment anatomy and axial length in adulthood. The Gutenberg Health Study is a population-based, observational cohort study in Germany. All participants underwent ocular biometry. Among the participants with follow-up and self-reported birth weight available, associations were assessed between low birth weight and anterior segment anatomy and axial length using multivariable linear regression analysis with adjustment for age and sex. In patients with phakia, anterior chamber depth and lens thickness were also examined. Data for this study were collected from April 27, 2012, through April 28, 2017, and analyzed from January through April 2018. Low birth weight. Corneal curvature, central corneal thickness, white-to-white distance, anterior chamber depth, lens thickness, and axial length. Overall, 11 294 eyes of 7120 participants were included (52.4% female; mean [SD] age, 56.2 [10.3] years). Most of the participants were white (98.6%). After adjustment for a...Continue Reading

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Citations

Dec 31, 2019·Acta Ophthalmologica·Markus J HaapanenMary Frances Cotch
Sep 30, 2020·Ophthalmic Epidemiology·Achim FießAlexander K Schuster
Nov 27, 2019·Investigative Ophthalmology & Visual Science·Achim FießAlexander K Schuster
Jan 5, 2021·Investigative Ophthalmology & Visual Science·Ling WeiXiangjia Zhu
Dec 24, 2020·Investigative Ophthalmology & Visual Science·Kathleen I C DyerSeyhan Yazar
Nov 11, 2021·Investigative Ophthalmology & Visual Science·Achim FießAlexander K Schuster

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