PMID: 702053Sep 1, 1978Paper

Association of low C2 and C4 serum levels with the HLA-DW2 allele in healthy individuals

The Journal of Experimental Medicine
C NerlG Valet

Abstract

HLA typed unrelated healthy individuals (HLA-DW2 positive n = 64, and HLA-DW2 negative n = 72) were investigated for their C2 functional activity and C4 serum protein levels. For the C2 and C4 levels a bimodal distribution was found in HLA-DW2 positive and HLA-DW2 negative individuals. HLA-DW2 positive persons had a significantly higher incidence of low C2 and C4 serum levels. Our data support the concept that genes governing C2 as well as C4 serum levels are in linkage disequilibrium with the HLA-DW2 allele of the major histocompatibility complex.

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Citations

Oct 1, 1990·Research in Immunology·A Marcelli-BargeJ Colombani
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P Mercier, R Panzani
Dec 1, 1983·Journal of the American Academy of Dermatology·L C Guenther
Aug 1, 1983·Journal of Immunogenetics·M R Laurent, K I Welsh
Jan 1, 1979·Clinical Neurology and Neurosurgery·G Ebers, D W Paty
Oct 1, 1986·Pathology·D L Gordon, M K Hostetter
Jan 1, 1981·Human Genetics·C Rittner, J Bertrams

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