Association of Low Vitamin D Levels with Noninfectious Uveitis and Scleritis

Ocular Immunology and Inflammation
Stephanie M LlopLucia Sobrin

Abstract

Purpose: To determine whether an association between Vitamin D and noninfectious ocular inflammation exists. Methods: Retrospective case-control study with 765 patients (333 uveitis cases, 103 scleritis cases, 329 controls). Logistic regression models examined the relationship between hypovitaminosis D and ocular inflammation. Results: The odds of having uveitis were 1.92 times higher for patients with hypovitaminosis D compared to patients with normal Vitamin D levels in the multivariate analysis [odds ratio (OR) = 1.92, 95% Confidence Interval (CI) = 1.36-2.72, p = 2.32 × 10-4]. A secondary analysis demonstrated that the odds of developing uveitis or scleritis were 5% lower and 4% lower, respectively, for every unit increase in Vitamin D level (uveitis: OR = 0.95, 95% CI = 0.94-0.97, p = 9.87 × 10-6; scleritis: OR = 0.96, 95% CI = 0.93-0.99, p = 0.009). Conclusion: Hypovitaminosis D was associated with increased risk of ocular inflammation in this retrospective study.

References

Feb 10, 2000·Archives of Biochemistry and Biophysics·C M VeldmanH F DeLuca
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BoonstraA O'Garra
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H F Deluca, M T Cantorna
Jul 20, 2002·Pharmacotherapy·Jennifer R McDuffieJack A Yanovski
Jan 20, 2004·Arthritis and Rheumatism·Linda A MerlinoUNKNOWN Iowa Women's Health Study
Jun 22, 2005·Survey of Ophthalmology·Narciss OkhraviSusan Lightman
Aug 12, 2008·The American Journal of Clinical Nutrition·Glenville Jones
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun TangRachel R Caspi
Oct 26, 2010·Nutrition·Maria C BorgesMarcelo M Rogero
Apr 30, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Alex UlitskyMazen Issa
Apr 30, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Cynthia Aranow
Aug 25, 2012·Investigative Ophthalmology & Visual Science·Yuan TianPeizeng Yang
Mar 13, 2014·International Journal of Rheumatic Diseases·Ilknur BaltaTurgay Celık
Aug 26, 2015·PLoS Medicine·Lauren E MokryJ Brent Richards
Mar 10, 2016·The American Journal of Gastroenterology·Toufic A KabbaniDavid G Binion
Mar 24, 2016·Ocular Immunology and Inflammation·Zeynep DadaciMehmet Borazan
Dec 23, 2016·JAMA Ophthalmology·Lindsay A GrottingLucia Sobrin

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Citations

Apr 8, 2020·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Aug 4, 2021·Survey of Ophthalmology·Shani Pillar, Radgonde Amer

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