Association of lower serum Brain-derived neurotrophic factor levels with larger infarct volumes in acute ischemic stroke

Journal of Neuroimmunology
Hui-Jie QiaoBin Wang

Abstract

Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS). The study population comprised consecutive patients with an AIS diagnosis who had been referred to our hospital between January 2015 and June 2016. The severity of stroke was evaluated by the National Institutes of Health Stroke Scale (NIHSS) at admission. Infarct volumes indicated by DWI were measured with MIPAV software. The relationship between median DWI infarct volume and serum BDNF level quartiles was evaluated using a semiparametric approach with univariate and multivariate quartile regression analysis. In this study, 270 patients were included and met the study criteria. The median DWI infarct volumes for the serum BDNF level quartiles (lowest to highest) were 10.56, 5.13, 3.75 and 2.43ml. Nonparametric Spearman rank correlation revealed a statistically significant negative correlation between serum BDNF level and DWI infarct volume (r=-0.363; P<0.001). The median DWI infarct volume in the lowest BDNF quartile was significantly larger than those in the uppe...Continue Reading

Citations

Nov 27, 2019·Translational Stroke Research·Tomás SobrinoJosé Castillo
Sep 3, 2020·Journal of Clinical Medicine·Aleksandra GaseckaCeren Eyileten
Nov 20, 2020·Brain Circulation·Poonam ChaturvediAnup Kumar Thacker
Oct 27, 2020·Journal of Family Medicine and Primary Care·Poonam ChaturvediAnup Kumar Thacker
Jan 12, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frederic MármolAlbert Martínez-Pinteño
Apr 4, 2021·Medicina·Eleni KarantaliIoannis Mavroudis
Sep 30, 2021·Irish Journal of Medical Science·Abdullah Sukun, Bulent Cekic

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