Association of macular pigment optical density with risk factors for wet age-related macular degeneration in the Indian population.

Eye
R RamanT Sharma

Abstract

To investigate macular pigment optical density (MPOD) in patients with and without wet age-related macular degeneration (AMD) and to elucidate the association between MPOD and the risk factors for AMD in an Indian population. Thirty-three subjects with wet AMD and 29 controls above 50 years old underwent MPOD measurement with the 'Macular Densitometer'. The subjects were also tested for their smoking history, lifetime ultraviolet (UV) exposure, dietary intake of carotenoids, and body mass index (BMI). Smokers had a higher risk for AMD than the non-smokers (P=0.032) and a lower MPOD level than non-smokers (mean (95% CI)) (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), adjusted P=0.026). Subjects with lowest UV exposure had higher MPOD than those with the highest (0.46 (0.38-0.54) vs 0.17 (0.01-0.33), P=0.01). MPOD was significantly lower among those with the lowest quartile of dietary intake of carotenoids (0.14 (0.08-0.21) vs 0.25 (0.13-0.36), P=0.012). Smoking, obesity, and UV index showed an inverse association with the MPOD. Low MPOD, smoking, and UV exposure had 5.11 (1.73-15.08), 3.54 (1.08-11.57), and 5.24 (1.06-25.96) odds for AMD, respectively, whereas higher dietary intake of carotenoids showed a protective effect for AMD. We f...Continue Reading

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Citations

Jan 7, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Robin G AbellNitin Verma
Jun 18, 2015·Nutrition Reviews·Geoffrey K BroadheadPeter McCluskey
Jul 1, 2020·Therapeutic Advances in Ophthalmology·Pinakin Gunvant DaveyStephanie Ammono-Monney
Mar 1, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Dimitra MakryniotiGeorge Lagoumintzis

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