Association of macular thickness with parapapillary atrophy in myopic eyes

BMC Ophthalmology
Helong PiaoSang Woo Park

Abstract

To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA+BM and PPA-BM, respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA+BM width and macular intraretinal...Continue Reading

References

Aug 17, 2005·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Seang-Mei SawWei-Han Chua
Apr 20, 2006·The British Journal of Ophthalmology·S-M Saw
Jul 11, 2006·Ophthalmology·Yasuyuki SuzukiUNKNOWN Tajimi Study Group
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Dennis Shun Chiu LamChristopher Kai-Shun Leung
Jul 2, 2010·Ophthalmology·Monika A CzudowskaNomdo M Jansonius
Oct 13, 2011·Investigative Ophthalmology & Visual Science·Sotaro OotoNagahisa Yoshimura
Jan 13, 2012·PloS One·Sujiv VurgeseJost B Jonas
Apr 25, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Elise HarbUNKNOWN COMET Study Group
Jul 5, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Young Hoon Hwang, Yong Yeon Kim
Oct 6, 2012·American Journal of Ophthalmology·Ignacio Flores-MorenoJosé M Ruiz-Moreno
Oct 25, 2012·PloS One·Jost B JonasSonghomitra Panda-Jonas
Jun 14, 2013·Investigative Ophthalmology & Visual Science·Nazli DemirkayaFrank D Verbraak
Apr 24, 2014·Ophthalmology·Giovanni StaurenghiUNKNOWN International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel
Sep 23, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hyun-Ho JungSang-Woo Park
Oct 16, 2014·Investigative Ophthalmology & Visual Science·Si ChenLin Xiao
Apr 22, 2015·American Journal of Ophthalmology·Elise HarbUNKNOWN COMET Study Group
Aug 21, 2015·International Ophthalmology·Janejit ChoovuthayakornVoraporn Chaikitmongkol
Nov 7, 2015·PloS One·Andrea SzigetiGábor Márk Somfai
Feb 11, 2016·Current Eye Research·Ming-Hui ZhaoLi-Li Jia
Jun 15, 2016·Investigative Ophthalmology & Visual Science·Jayme R ViannaMarcelo T Nicolela
Oct 19, 2016·American Journal of Ophthalmology·Melinda Y ChangJoseph L Demer
Jan 7, 2017·Seminars in Ophthalmology·Rasha BarhamPaolo S Silva
Feb 7, 2017·Investigative Ophthalmology & Visual Science·Chee Wai WongChui Ming Gemmy Cheung
Apr 21, 2017·Retina·Jost B JonasKyoko Ohno-Matsui
Jun 28, 2017·Investigative Ophthalmology & Visual Science·Wendy L Marsh-TootleUNKNOWN for the Correction of Myopia Evaluation Trial (COMET) Study Group
Feb 9, 2018·American Journal of Ophthalmology·Mi Sun SungSang Woo Park
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Qi ZhangJost B Jonas
Aug 12, 2018·Investigative Ophthalmology & Visual Science·Kyoung Min LeeSeok Hwan Kim
May 3, 2019·Ophthalmology Retina·Alessandro InvernizziGiovanni Staurenghi
Oct 1, 2019·Journal of Glaucoma·Mi Sun SungSang Woo Park

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