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Association of mannose-binding lectin 2 gene polymorphic variants with susceptibility and clinical progression in systemic lupus erythematosus

Clinical and Experimental Rheumatology

Dec 31, 2011

Nadine GlesseJosé Artur Bogo Chies

PMID: 22206649

Abstract

This study investigates the role of mannose-binding lectin (MBL) in susceptibility and clinical expression of systemic lupus erythematosus (SLE), through the analysis of promoter region and exon 1 polymorphisms of the MBL2 gene. We analysed 325 SLE patients from the Hospital de Clínicas...read more

Mentioned in this Paper

Mannose Binding Lectin
Exons
Promoter
MBL2 protein, human
Ethnic Group
MBL2 gene
Lupus Erythematosus, Systemic
Mannose-Binding Protein Deficiency
Genetic Polymorphism
Genetic Predisposition to Disease
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Association of mannose-binding lectin 2 gene polymorphic variants with susceptibility and clinical progression in systemic lupus erythematosus

Clinical and Experimental Rheumatology

Dec 31, 2011

Nadine GlesseJosé Artur Bogo Chies

PMID: 22206649

DOI:

Abstract

This study investigates the role of mannose-binding lectin (MBL) in susceptibility and clinical expression of systemic lupus erythematosus (SLE), through the analysis of promoter region and exon 1 polymorphisms of the MBL2 gene. We analysed 325 SLE patients from the Hospital de Clínicas...read more

Mentioned in this Paper

Mannose Binding Lectin
Exons
Promoter
MBL2 protein, human
Ethnic Group
MBL2 gene
Lupus Erythematosus, Systemic
Mannose-Binding Protein Deficiency
Genetic Polymorphism
Genetic Predisposition to Disease

Similar Papers Found In These Feeds

Complement Pathway: Mannose-Binding Lectin

The Mannose-Binding Lectin Complement Pathway is activated when mannose-binding lectin binds to mannose found on the surface of pathogens. Subsequent complement activation is similar to the classical complement pathway, but without the need for antigen-antibody complexes. Discover the latest research here.

Systemic Lupus Erythematosus

Systemic lupus erythematosus is an autoimmune disorder which can affect and damage any organ system in the body. It has a diverse range of immunological manifestations and is more prominent in young women, with the exact etiology still unknown. Here is the latest research on systemic lupus erythematosus.

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