Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.

Journal of Cellular and Molecular Medicine
Wang-Dong XuAn-Fang Huang

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder. MASP2 is a mediator that plays an important role in complement system. As dysregulation of the complement system has been demonstrated to correlate with SLE pathogenesis, the role of MASP2 in lupus has not been widely discussed. In the present study, serum levels of MASP2 were evaluated in 61 lupus patients and 98 healthy controls by training cohort, and then a validation cohort including 100 lupus, 100 rheumatoid arthritis, 100 osteoarthritis, 100 gout, 44 Sjogren's syndrome, 41 ankylosing spondylitis patients confirmed the findings. Receiver operating characteristic (ROC) curve analysis determined the discriminatory capacity for serum MASP2. PCR methods tested the association of MASP2 gene polymorphisms (rs7548659, rs17409276, rs2273346, rs1782455 and rs6695096) and SLE risk. Impact of polymorphism on MASP2 serum levels was evaluated as well. Results showed that serum levels of MASP2 were significantly higher in lupus patients and correlated with some clinical, laboratory characteristics in the training cohort, and were much higher as compared to that in different rheumatic diseases patients in the validation cohort. Serum MASP2 showed a good di...Continue Reading

References

Apr 1, 1977·Arthritis and Rheumatism·S L WallaceT F Yü
Nov 1, 1988·Psychological Medicine·H M McCormackS Sheather
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Apr 5, 2011·Rheumatology International·C G AmmitzbollK Stengaard-Pedersen
Apr 12, 2015·Molecular Immunology·Marcia H BeltrameIara Messias-Reason
Aug 26, 2016·Nature Reviews. Rheumatology·Erin E CarterAnn E Clarke
Jul 26, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nirmal K BandaV Michael Holers
Aug 11, 2017·Nature Reviews. Rheumatology·Leendert A TrouwAnna M Blom

❮ Previous
Next ❯

Citations

May 26, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Vijaya KnightNicholas L Rider

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
genotyping
PCR

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved