Association of mast cells and liver allograft rejection

Pediatric Transplantation
Cigdem ArikanSema Aydogdu

Abstract

MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy with normal histopathology n = 5 and naive livers n = 6), transplanted livers with CR (n = 5), and transplanted livers with ACR (n = 26) were studied. The total number of PT in each biopsy specimen was documented, and the number of PT that contained MCs was expressed as a percentage of the total number of PT. MCs, percentage of PT containing MCs and the average number of MCs/PT was significantly higher in rejection specimens than in control biopsy samples. All parameters were significantly higher in CR group than AR groups. Increasing grades of rejection was also associated with progressively more MCs and MC/PT (r = 0.68 p = 0.000; r = 0.58 p = 0.002). Only serum bilirubin level was related to the MCs in AR group. Only MC/PT was detected as an independent predictor of graft survival (p = 0.011, RR 2.87 95% CI 1.3-6.5). Despite the fact that the role of MCs in liver allograft rejection is still unknown; they exist i...Continue Reading

References

Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W HagmannU Buchholz
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerR A Krom
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J FarrellA D Burt
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Feb 1, 1994·Current Opinion in Immunology·L B Schwartz
Feb 1, 1997·Human Pathology·S A Yousem
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F Levi-Schaffer, V B Weg
Jan 9, 1998·Transplantation·O AbbasogluG B Klintmalm
Dec 16, 1998·Virchows Archiv : an International Journal of Pathology·M YamashiroY Nakanuma
Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R C Benyon
Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerR A Krom
Dec 23, 1999·Current Opinion in Hematology·S J Galli
Dec 2, 2000·Journal of Pediatric Surgery·A F Uddin AhmedR Ohi
Dec 29, 2000·Journal of Hepatology·T Terada, Y Matsunaga
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cathal O'KeeffeP Aiden McCormick
Feb 14, 2002·Clinical Nephrology·H Abo-ZenahA M El Nahas
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Desley A H Neil, Stefan G Hubscher
Dec 5, 2002·Clinical Transplantation·Eizo GotoHisao Ito
Mar 12, 2003·Current Rheumatology Reports·Barry L Gruber
May 10, 2005·Transplantation·Jong-Sun KimDieter C Broering
Nov 5, 2005·Pediatric Transplantation·S AydogduY Tokat

❮ Previous
Next ❯

Citations

May 6, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Veronica JaridoHeather Francis
Dec 6, 2018·Frontiers in Immunology·Flavie Ngo NyekelGregory Gautier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Manal F Abdelmalek, Anna Mae Diehl
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jacob AlexanderKris V Kowdley
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Ulf P Neuman, Peter Neuhaus
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
V BalanR H Wiesner
© 2022 Meta ULC. All rights reserved