Association of maternal caffeine intake during pregnancy with low birth weight, childhood overweight, and obesity: a meta-analysis of cohort studies.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Feng Jin, Chong Qiao

Abstract

Epidemiological studies reported inconsistent results on the associations between maternal caffeine intake during pregnancy and risk of low birth weight (LBW) and childhood overweight and obesity in their offspring. We conducted a meta-analysis of cohort studies to quantitatively assess these associations. Pertinent studies were identified by searching PubMed and Embase through June 2019. Study-specifics risk estimates were combined using fixed effects models, or random-effects models when significant heterogeneity was detected. Dose-response analysis was modeled by using restricted cubic splines. A total of 15 cohort studies, with 102,347 pregnancy women, was included in the meta-analysis. The pooled relative risk (RR) for LBW was 1.33 (95% CI: 1.12, 1.57) for mothers with the highest compared with the lowest level of caffeine intake during pregnancy, with significant heterogeneity across studies (I2 = 49.3%, P = 0.032). The pooled RR was 1.07 (95% CI: 1.02, 1.11) for each 100 mg/day increase of caffeine intake. The pooled RR for childhood overweight and obesity was 1.39 (95% CI: 1.15, 1.69) for mothers with the highest compared with the lowest level of caffeine intake during pregnancy. No significant heterogeneity across stud...Continue Reading

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Citations

Feb 3, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Sanaz SoltaniAhmad Esmaillzadeh
Nov 9, 2021·JAMA Network Open·Stefanie N HinkleCuilin Zhang
Jan 16, 2022·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jennifer Kusumah, Elvira Gonzalez de Mejia

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