Association of maternal diabetes with attention deficit/hyperactivity disorder (ADHD) in offspring: A meta-analysis and review

Diabetes Research and Clinical Practice
Dan GuoJiazhen Dai

Abstract

Researches on the relationship between maternal pregestational or gestational diabetes and attention deficit/hyperactivity disorder (ADHD) in offspring provided inconsistent findings; therefore, we performed an updated and comprehensive literature review and meta-analysis to evaluate the available evidence. Relevant articles in Pubmed, Web of Science, Cochrane, Embase, and Wanfang database published until January 2019 were searched without language restriction. We performed a meta-analysis about maternal pregestational and gestational diabetes and risk of ADHD in offspring using odds ratio (OR), relative risk (RR), hazard ratio (HR) and 95% confidence interval (95% CI) extracted from each study. Seven articles were included in this study and a total of 3,169,529 participants were accumulated. We found maternal pregestational diabetes increased the risk of ADHD in offspring by 44% (95% CI was 1.32-1.57). Maternal pregestational diabetes is a potential adverse risk of ADHD in offspring. Considering the limited amount of reliable information availabe. In the future, more in-depth and detailed researches, especially population-based prospective cohort studies, are needed to explore this topic more comprehensively.

Citations

Dec 29, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L BovbjergMelissa Cheyney

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