Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones: The Hokkaido birth cohort study

Environmental Research
Sachiko ItohReiko Kishi

Abstract

Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for thyroid hormones (TH) is limited, and the underlying mechanism remains unknown. We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and maternal and neonatal TH levels, taking the maternal-fetal TH transfer into account. In this prospective birth cohort (the "Hokkaido study") we included 222 mother-neonate pairs. We measured five OH-PCB isomers in maternal serum samples either during pregnancy or within 5 days of delivery. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from maternal blood samples at an early gestational stage (median; 11.1 weeks) and from heel prick samples of neonates between 4 and 7 days after birth. Multiple linear regression analysis and structural equation modeling (SEM) were performed to investigate the associations between maternal OH-PCB and maternal and neonatal TH levels. Median concentration of ∑OH-PCBs was 25.37 pg/g wet weight. The predominant isomer was 4-OH-CB187, followed by 4-OH-CB146+3-OH-CB153. In the fully adjusted linear regression analysis, maternal ∑OH-PCBs was positively associated with maternal FT4, and 4-OH-CB187 was positively a...Continue Reading

Citations

Nov 13, 2019·Environmental Science and Pollution Research International·Carolyn KlockePamela J Lein
Feb 9, 2020·International Journal of Molecular Sciences·Carolyn Klocke, Pamela J Lein
Apr 13, 2019·Acta Neuropathologica·Isaac N PessahSharon K Sagiv
Sep 23, 2020·Toxics·Harmanpreet Kaur PanesarPamela J Lein
Jul 22, 2020·Current Opinion in Pediatrics·Lorenzo IughettiSergio Bernasconi
Jan 20, 2021·Annals of the Academy of Medicine, Singapore·Karen M L TanShiao Yng Chan
May 24, 2021·Environmental Health and Preventive Medicine·Reiko KishiUNKNOWN members of The Hokkaido Study on Environment and Children’s Health

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