Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Song HeThiam Chye Tan

Abstract

To investigate the association of serum progesterone in first trimester with low birth weight (LBW, birth weight <2500 g) and other adverse pregnancy outcomes including hypertensive disorders of pregnancy, preterm delivery, premature rupture of membranes at term, and preterm premature rupture of membranes in a general population. We conducted a cohort study of 263 women with low-risk singleton intrauterine pregnancies who had a spot serum progesterone measurement in the first trimester in a Singapore tertiary maternity hospital. Study outcomes were retrieved from clinical records. Follow-up data were available for 131 women. Univariate and multivariate logistic regression analyses were performed to assess the association of low serum progesterone (<35 nmol/L) with LBW and other adverse pregnancy outcomes. Low serum progesterone was associated with a significantly increased risk of LBW (adjusted odds ratio: 5.28 [1.02, 27.3]; p=0.047). Low serum progesterone was associated with a significantly increased risk of hypertensive disorders of pregnancy in univariate analysis (unadjusted odds ratio: 8.43 [1.31, 54.2]; p=0.025). Low serum progesterone in the first trimester is a significant risk factor for LBW and possibly other placent...Continue Reading

References

Apr 30, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·V T ValleyM B Phelan
Jan 5, 2001·Human Reproduction·P Kristiansson, J X Wang
Mar 8, 2002·The New England Journal of Medicine·Laura A SchieveLynne S Wilcox
Sep 15, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Lise Dubois, Manon Girard
Aug 8, 2007·American Journal of Reproductive Immunology : AJRI·Petra ArckJulia Szekeres-Bartho
Jul 12, 2008·Reproductive Biomedicine Online·Petra C ArckBurghard F Klapp
Aug 8, 2008·Medicine and Science in Sports and Exercise·Martin D Hoffman
Aug 30, 2008·American Journal of Epidemiology·T F McElrathUNKNOWN ELGAN Study Investigators
Oct 1, 2008·Seminars in Reproductive Medicine·Suleena Kansal Kalra, Thomas A Molinaro
Feb 12, 2009·Reproductive Sciences·John R ChallisFelice Petraglia
Mar 10, 2009·Human Reproduction Update·R H F van OppenraaijUNKNOWN ESHRE Special Interest Group for Early Pregnancy (SIGEP)
Jun 4, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M BettiP Ghirri
Jan 25, 2011·American Journal of Obstetrics and Gynecology·Han-Yang ChenRon A Cisler
Jun 3, 2011·Journal of Reproductive Immunology·E MikoJ Szekeres-Bartho
Oct 11, 2012·Human Reproduction·Isabel R V HartwigPetra C Arck
Jul 23, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shannon DibbleJawed Fareed
Oct 17, 2013·Diabetology & Metabolic Syndrome·Carlos Antonio Negrato, Marilia Brito Gomes
Jun 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Chee Wai KuThiam Chye Tan

❮ Previous
Next ❯

Citations

Jan 12, 2016·Hormone Molecular Biology and Clinical Investigation·Jia Ying GohThiam Chye Tan
Jul 6, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M MaliqueoN Crisosto
Nov 27, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Song-Ying ShenXiu Qiu
Oct 7, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sandra L RebholzLaura A Woollett
May 22, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Katherine SvenssonHeather H Burris
Sep 12, 2018·Nature Microbiology·Stephanie Stanelle-BertramGülsah Gabriel
Mar 13, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yassaman VafaiKatherine L Grantz
Apr 27, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Baoying FengDongping Huang
Feb 6, 2018·Journal of Proteome Research·Oliver RobinsonMarc Chadeau-Hyam
Sep 10, 2021·Frontiers in Cellular and Infection Microbiology·Chengjun HuHanlin Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.