Association of Maternal Thyroid Function and Thyroidal Response to Human Chorionic Gonadotropin with Early Fetal Growth

Thyroid : Official Journal of the American Thyroid Association
Yong ZhangJianxia Fan

Abstract

Early pregnancy fetal growth is a relevant determinant of pregnancy outcome and child health during later life. During the first trimester, fetal growth depends on the transfer of maternal thyroid hormone, and optimal thyroid hormone availability is ensured via stimulation of the maternal thyroid by human chorionic gonadotropin (hCG). The potent stimulatory effects of hCG on gestational thyroid function and its clinical relevance with early fetal growth remain unknown and need to be examined. This study comprised 46,186 mothers for whom early pregnancy thyrotropin (TSH), free thyroxine (fT4), triiodothyronine, thyroperoxidase antibodies, hCG, as well as ultrasound crown-rump length (CRL) measurements were available. Data were also available on potential confounders, including maternal age, parity, anthropometrics, and fetal sex. There was a negative association of TSH with CRL and a positive association of fT4 with CRL, with effect estimates of roughly 0.1 standard deviation (SD) across the full ranges. However, when taking into account thyroid stimulation by hCG, an impaired thyroidal response to hCG stimulation was associated with up to a 0.2 SD lower CRL (high hCG with high TSH) and up to a 0.6 SD lower CRL (high hCG with lo...Continue Reading

References

Feb 21, 1991·The New England Journal of Medicine·J G Thorpe-BeestonA M McGregor
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·D GlinoerB Lejeune
Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·R HoermannS M Amir
Dec 17, 1998·The New England Journal of Medicine·G C SmithJ E Fleming
Jun 7, 2003·BMJ : British Medical Journal·Rulla M TamimiDimitrios Trichopoulos
Mar 16, 2007·BMJ : British Medical Journal·Radek BukowskiUNKNOWN FASTER Research Consortium
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naomi M ScottVicki L Clifton
Feb 11, 2010·JAMA : the Journal of the American Medical Association·Dennis O Mook-KanamoriVincent W V Jaddoe
Jan 21, 2012·Fertility and Sterility·Clarisa R GraciaSusan J Mandel
Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Marco MediciEric A P Steegers
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·James E HaddowUNKNOWN First and Second Trimester Risk of Aneuploidy (FaSTER) Research Consortium
Jul 24, 2015·The Journal of Clinical Endocrinology and Metabolism·Tim I M KorevaarRobin P Peeters
Sep 21, 2016·The Journal of Clinical Endocrinology and Metabolism·Tim I M KorevaarRobin P Peeters
Nov 18, 2016·The Journal of Endocrinology·Juan Bernal
Jan 5, 2017·Thyroid : Official Journal of the American Thyroid Association·Tim I M KorevaarRobin P Peeters
Jan 28, 2017·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jinyan FuDaozhen Chen
Mar 31, 2017·The Journal of Clinical Endocrinology and Metabolism·Tanja G M VrijkotteMarcel B Twickler
Jul 5, 2017·Frontiers in Pediatrics·Mohammed Al-Qaraghouli, Yu Ming Victor Fang
Jul 21, 2017·European Journal of Endocrinology·Mirjana BarjaktarovicRobin P Peeters
Aug 5, 2017·Nature Reviews. Endocrinology·Tim I M KorevaarRobin P Peeters
Sep 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Tim I M KorevaarRobin P Peeters
Dec 7, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sehar Iqbal, Cem Ekmekcioglu
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Arash DerakhshanRobin P Peeters

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Citations

Feb 24, 2021·Thyroid : Official Journal of the American Thyroid Association·Yindi LiuJianxia Fan

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