Association of matrix metalloproteinase-7A-181G variants with the risk of multiple sclerosis

Personalized Medicine
Ziba RahimiFarid Najafi

Abstract

To investigate the influence of matrix metalloproteinase-7 (MMP-7) A-181G on the risk of multiple sclerosis (MS) and neurological disability. The variants of MMP-7 were studied in 126 MS patients and 190 healthy controls. The MMP-7 G allele and AG+GG genotype significantly increased the risk of MS in females (odds ratio: 1.59; p = 0.011) and patients with the age at disease onset of ≤19 years (odds ratio: 8.77; p = 0.038), respectively. Patients with clinical course of secondary progressive MS carriers of AG genotype had higher mean Expanded Disability Status Scale (4.9 ± 0.85; p = 0.01) compared with carriers of AA genotype (3.75 ± 0.41). The MMP-7 A-181G polymorphism might be associated with susceptibility to MS in females and individuals with the age at disease onset of ≤19 years and with neurological disability in secondary progressive MS.

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